Clinical Course and Nutritional Management of Propionic and Methylmalonic Acidemias

Table 6

Correlation between IQ/DQ and the clinical course, growth centiles, nutrition, and biochemical investigations.

	IQ/DQ level
(1) Clinical course	r	value
(i) Time delay between first symptoms and diagnosis	−0.51	0.021
(ii) Age of diagnosis	−0.08	0.74
(iii) Number of attacks in first year	−0.039	0.088
(iv) Number of attacks per year	−0.53	0.015
(v) Length of hospital stay in first attack	−0.86	<0.001
(vi) Number of ICU admissions	−0.66	0.002
(vii) Length of hospital stay	−0.87	<0.00001
(2) Nutritional status and growth percentiles
(i) Total protein intake	−0.03	0.2
(ii) Natural protein intake	0.3	0.2
(iii) Synthetic protein intake	−0.16	0.5
(iv) Natural to synthetic protein ratio	0.31	0.18
(v) Length/height	0.43	0.06
(vi) Weight	0.37	0.1
(vi) Head circumference	0.48	0.032
(3) Biochemical investigations in the first attack
(i) Ammonia	−0.25	0.28
(ii) Lactate	−0.13	0.57
(iii) Bicarbonate	−0.02	0.93
(iv) pH	0.1	0.66
(v) C3	−0.2	0.38
(vi) C3: C2	0.21	0.37
(vii) Glycine	−0.2	0.39

Statistical significance with .