Clinical Course and Nutritional Management of Propionic and Methylmalonic Acidemias

Table 7

Comparison between PA and MMA groups.

Variable	Total	PA	MMA	value
	Mean ± SD
Dietary intake (gm/kg/day)
(i) Total protein	2.097 ± 0.24	2.075 ± 0.28	2.12 ± 0.2	0.69
(ii) Natural protein	0.73 ± 0.99	0.71 ± 0.09	0.75 ± 0.1	0.32
(iii) Synthetic amino acid formula	1.37 ± 0.24	1.38 ± 0.26	1.36 ± 0.23	0.86
(iv) Natural protein: synthetic protein	0.55 ± 0.13	0.53 ± 0.13	0.55 ± 0.13	0.54
Anthropometric measures (percentiles)
(i) Length/height	10.85 ± 6.71	8.6 ± 5.56	13.1 ± 7.27	0.13
(ii) Head circumference	26.25 ± 14.13	25 ± 15.09	27.5 ± 13.79	0.7
(iii) Weight	21.25 ± 14.03	17.5 ± 13.59	25 ± 14.14	0.24
Clinical course
(i) Length of hospital stay	5.55 ± 4.35	8.4 ± 4.4.59	0.33 ± 0.5	0.003
(ii) Length of hospital stay	6.1 ± 0.65	7.9 ± 3.1	4.3 ± 1.15	0.005
(iii) Decompensation episodes per year	1.9 ± 1.15	2.6 ± 1.07	1 ± 0.43	0.003
(iv) PICU admission frequency	0.9 ± 1.02	1.3 ± 1.15	0.33 ± 0.5	0.04
(v) Attacks in the first year	2.32 ± 1.34	2.8 ± 1.47	1.6 ± 0.8	0.14
(vi) IQ/DQ	83. ± 0.24	70 ± 23.09	97.1 ± 6.22	0.004

During the initial decompensation episode and after the initial episode.