Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials

Table 4

Summary of clinical trials using Punica granatum (pomegranate) in other disorders.

Disease	Treatment	No. of patients	Study design	Dosage/duration	Outcomes	References
Chronic obstructive pulmonary disease (COPD)	(i) PJ; (ii) Synthetic orange-flavoured drink	30	Double‐blind, RCT	400 ml daily/5 weeks	No useful effect in patients with COPD.	[75]
Anxiety during dental treatment in children	Group I: Pepsi Cola + 0.75 mg/kg midazolam; Group II: 10% sodium citrate + 0.75 mg/kg midazolam; Group III: PJ + 0.75 mg/kg midazolam; Group IV: grape fruit juice + 0.75 mg/kg midazolam; Group V: 0.75 mg/kg midazolam orally	75	Double‐blind, RCT	Two milliliter each of compounds added to midazolam in equal volumes of 15 mg/3 ml	Increase in the effectiveness of sedation with addition of sodium citrate to the midazolam.	[76]
Ischemic stroke	(i) Pomegranate polyphenol pills; (ii) Placebo pills	16	Double‐blind, RCT	Twice per day/one week	Improvement of cognitive and functional recovery after stroke.	[77]
Infants with intrauterine growth restriction	(i) PJ; (ii) Placebo juice	55	Double‐blind, RCT	8 oz daily/until delivery	PJ altered white matter organization and functional connectivity in the infant brain.	[78]
Memory dysfunction in heart surgery	(i) POMx pills; (ii) Placebo pills	10	Pilot study	2 pills daily/7 weeks	Improvement of memory retention skill after surgery.	[79]
Illnesses related to stress	OCTA© compound mixture of eight herbs including Punica granatum	17	Open-label and uncontrolled clinical trial	30 ml daily/3 months	Improvement of perceptions of stress and quality of life.	[80]
Hypercholesterolemia	(i) Malas variety of PJ; (ii) Black variety of PJ; (iii) Lovastatin	36	Clinical study	200 ml daily/4 weeks	Reduction of plasma TC and LDL ().	[81]