The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity
Table 1
Anthropometrical and biochemical features of the obese group versus controls.
Variables
Cases (N = 63)
Controls (N = 27)
value
Age (years)
10 (9–13)
9 (7–12)
0.41
Sex, male (n, %)
42 (66.7)
16 (59.3)
0.67
BMI (kg/m2)
28.2 (26.1–33.2)
15.7 (14.1–18.0)
<0.001
BMI-SDS
2.3 (2.0–2.6)
−0.5 ((−1.3)–0.4)
<0.001
Hb (g/dl)
13.3 (12.8–13.9)
13.2 (12.3–13.9)
0.38
Hct (%)
39.9 (38.2–41.3)
39.2 (37–40.9)
0.39
MCV (fl)
76.6 (74.0–80.0)
76.8 (69.9–83.1)
0.76
Serum iron (mcg/dl)
69.0 (50.0–91.0)
54.0 (38.0–73.0)
0.03
Ferritin (ng/ml)
77.0 (51.4–114.0)
55.0 (35.0–77.1)
0.03
TIBC (mg/dl)
410.0 (377.0–447.0)
193.0 (176.0–323.0)
<0.001
Transferrin saturation (%)
15.2 (12.5–25.6)
26.6 (17.0–29.4)
0.001
Hepcidin-25 (ng/ml)
26.2 (12.9–45.6)
19.7 (8.3–25.5)
0.02
BMI: body mass index; BMI-SDS: body mass index-standard deviation score; Hb: hemoglobin; Hct: hematocrit; MCV: mean corpuscular volume; TIBC: total iron binding capacity. All data were expressed as median (IQR) except sex (n, %); value from Wilcoxon rank-sum test.
