The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity
Table 3
Comparison of BMI-SDS, iron profiles, and serum hepcidin-25 among children with obesity and ID, children with obesity without ID, and controls.
Obese with ID (A) (N = 27)
Obese without ID (B) (N = 36)
Controls (C) (N = 27)
value† overall
value§ for A vs. B
value§ for A vs. C
value§ for B vs. C
BMI-SDS
2.3 (2.0–2.7)
2.4 (2.0–2.6)
−0.5 ((−1.3)−0.4)
<0.001
0.81
<0.001
<0.001
Hb (g/dl)
13.1 (12.5–13.9)
13.4 (12.8–14.1)
13.2 (12.3–13.9)
0.43
0.35
0.84
0.22
Hct (%)
39.2 (37.9–41.1)
39.9 (38.4–41.4)
39.2 (37–40.9)
0.57
0.53
0.72
0.29
Serum iron (mcg/dl)
48 (42–57)
87.5 (70–106.5)
54 (38–73)
<0.001
<0.001
0.30
<0.001
Ferritin (ng/ml)
77 (50.4–114)
82.2 (52.3–107.9)
55 (35–77.1)
0.08
0.96
0.06
0.04
TIBC (mg/dl)
414 (388–487)
403 (349.5–438)
193 (176–323)
<0.001
0.10
<0.001
<0.001
Transferrin saturation (%)
12.1 (10.5–14.6)
23.4 (17.7–27.1)
26.6 (17–29.4)
<0.001
<0.001
<0.001
0.55
Hepcidin-25 (ng/ml)
25 (12.9–49.2)
26.4 (12.6–43.6)
19.7 (8.3–25.5)
0.06
0.85
0.04
0.04
Iron intake (mg/day)
6.6 (5.1–7.8)
6.7 (5.8–7.7)
NA
0.73
NA
NA
NA
All data were expressed as median (IQR), BMI-SDS: body mass index-standard deviation score; Hb: hemoglobin; Hct: hematocrit; MCV: mean corpuscular volume; TIBC: total iron binding capacity; † value for compared median between the obese with ID, obese without ID, and control using Kruskal–Wallis test. § value for compared median between two groups using Wilcoxon rank-sum test.
