Lipoprotein Levels in Early Adulthood and NAFLD in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Table 4
ApoB cholesterol levels and concordance/discordance between ApoB and cholesterol categories in relation to odds of Y25 moderate-severe NAFLD.
OR (95% CI)
N
Unadjusted
Multivariable adjusted†
ApoB tertiles
Low (referent)
883
1.00
1.00
Middle
885
1.29 (0.93, 1.81)
1.18 (0.83, 1.68)
High
897
1.74 (1.26, 2.39)
1.24 (0.88, 1.75)
LDL-C tertiles
Low (referent)
898
1.00
1.00
Middle
869
1.21 (0.87, 1.67)
1.07 (0.76, 1.51)
High
898
1.47 (1.08, 2.02)
1.11 (0.79, 1.56)
NHDL-C tertiles
Low (referent)
879
1.00
1.00
Middle
910
1.29 (0.92, 1.81)
1.12 (0.78, 1.59)
High
876
1.87 (1.36, 2.59)
1.26 (0.89, 1.79)
TG tertiles
Low (referent)
894
1.00
1.00
Middle
884
1.41 (0.98, 2.05)
1.21 (0.82, 1.77)
High
887
3.06 (2.19, 4.27)
1.87 (1.30, 2.69)
ApoB/TG ratio quartiles
Low
666
2.85 (1.93, 4.22)
1.98 (1.30, 3.01)
Middle
666
2.26 (1.51, 3.37)
1.78 (1.17, 2.72)
High
667
1.28 (0.83, 1.99)
1.21 (0.77, 1.91)
Highest (referent)
666
1.00
1.00
ApoB/LDL-C
Low/low (referent)
1107
1.00
1.00
Low/high
219
0.84 (0.48, 1.46)
0.80 (0.45, 1.42)
High/low
238
1.25 (0.79, 1.99)
0.87 (0.52, 1.47)
High/high
1101
1.13 (0.84, 1.53)
0.94 (0.69, 1.29)
ApoB/NHDL-C
Low/low (referent)
1125
1.00
1.00
Low/high
201
0.79 (0.44, 1.55)
0.60 (0.32, 1.12)
High/low
206
0.89 (0.51, 1.55)
0.82 (0.46, 1.47)
High/high
1133
1.46 (1.11, 1.92)
1.03 (0.76, 1.39)
ApoB/TG
Low/low (referent)
861
1.00
1.00
Low/high
465
2.01 (1.36, 2.97)
1.48 (1.01, 2.24)
High/low
480
0.91 (0.57, 1.45)
0.86 (0.51, 1.45)
High/high
859
2.50 (1.79, 3.48)
1.69 (1.09, 2.61)
Median ApoB: 88.0 g/dl; median LDL-C: 107.0 mg/dL; median non-HDL-C: 121.0 mg/dL; median TG: 60 mg/dL. Moderate-severe NAFLD was defined as LA ≤40 HU after exclusion for other causes of liver fat. †The multivariable adjusted model was adjusted for age, sex, race, field center, educational attainment, + baseline (smoking status and alcohol (g/day), waist circumference, physical activity, systolic BP, antihypertensive medication use, and fasting blood glucose; ApoB/LDL-C was adjusted for TG, ApoB/TG was adjusted for LDL-C).
