Research Letter

Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention

Figure 1

Spectral evolution of the SP band showing the assembly of DNA capped nanoparticles (A1 and A2) in the presence of a target DNA (T1) (a), the reactivity upon heating and cooling of solution-A (b), and the reactivity upon heating and cooling of solution-A in the presence of an uncleaved DNA (P1) (c). TEM images of samples from A1, A2, and the assemblies are included in the left panel for comparison. (Note that the scale bar for the assemblies is smaller in order to show the degree of clustering.) Concentration for various components: [ A u n m ] = 3 . 3  nM; [DNA1 or DNA2] = 1.0  𝜇 M; [T1] = 0.1  𝜇 M; [P1] = 1.2  𝜇 M.
527294.fig.001a
(a)
527294.fig.001b
(b)
527294.fig.001c
(c)