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Journal of Nanotechnology
Volume 2009, Article ID 184702, 14 pages
http://dx.doi.org/10.1155/2009/184702
Review Article

Applying Nanotechnology to Human Health: Revolution in Biomedical Sciences

Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

Received 20 May 2009; Accepted 20 June 2009

Academic Editor: Chuan-Jian Zhong

Copyright © 2009 Siddhartha Shrivastava and Debabrata Dash. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Zandonella, “Cell nanotechnology: the tiny toolkit,” Nature, vol. 423, no. 6935, pp. 10–12, 2003. View at Publisher · View at Google Scholar
  2. E. Klarreich, “Biologists join the dots,” Nature, vol. 413, no. 6855, pp. 450–452, 2001. View at Publisher · View at Google Scholar
  3. A. Curtis and C. Wilkinson, “Nantotechniques and approaches in biotechnology,” Trends in Biotechnology, vol. 19, no. 3, pp. 97–101, 2001. View at Publisher · View at Google Scholar
  4. B. Roszek, W. H. De Jong, and R. E. Geertsma, “Nanotechnology in medical applications: state-of-the-art in materials and devices,” Tech. Rep. 265001001, RIVM, Bilthoven, The Netherlands, 2005. View at Google Scholar
  5. W. C. W. Chan and S. Nie, “Quantum dot bioconjugates for ultrasensitive nonisotopic detection,” Science, vol. 281, no. 5385, pp. 2016–2018, 1998. View at Publisher · View at Google Scholar
  6. A. Vaseashta and D. Dimova-Malinovska, “Nanostructured and nanoscale devices, sensors and detectors,” Science and Technology of Advanced Materials, vol. 6, no. 3-4, pp. 312–318, 2005. View at Publisher · View at Google Scholar
  7. R. Langer, “Drugs on target,” Science, vol. 293, no. 5527, pp. 58–59, 2001. View at Publisher · View at Google Scholar
  8. S. Jin and K. Ye, “Nanoparticle-mediated drug delivery and gene therapy,” Biotechnology Progress, vol. 23, no. 1, pp. 32–41, 2007. View at Publisher · View at Google Scholar
  9. E. Sachlos, D. Gotora, and J. T. Czernuszka, “Collagen scaffolds reinforced with biomimetic composite nano-sized carbonate-substituted hydroxyapatite crystals and shaped by rapid prototyping to contain internal microchannels,” Tissue Engineering, vol. 12, no. 9, pp. 2479–2487, 2006. View at Publisher · View at Google Scholar
  10. S. Shrivastava, T. Bera, A. Roy, G. Singh, P. Ramachandrarao, and D. Dash, “Characterization of enhanced antibacterial effects of novel silver nanoparticles,” Nanotechnology, vol. 18, no. 22, pp. 225103–225111, 2007. View at Publisher · View at Google Scholar
  11. D. Nepal, S. Balasubramanian, A. L. Simonian, and V. A. Davis, “Strong antimicrobial coatings: single-walled carbon nanotubes armored with biopolymers,” Nano Letters, vol. 8, no. 7, pp. 1896–1901, 2008. View at Publisher · View at Google Scholar
  12. A. Panacek, L. Kvitek, R. Prucek et al., “Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity,” Journal of Physical Chemistry B, vol. 110, no. 33, pp. 16248–16253, 2006. View at Publisher · View at Google Scholar
  13. J. R. Morones, J. L. Elechiguerra, A. Camacho et al., “The bactericidal effect of silver nanoparticles,” Nanotechnology, vol. 16, no. 10, pp. 2346–2353, 2005. View at Publisher · View at Google Scholar
  14. C. Baker, A. Pradhan, L. Pakstis, D. J. Pochan, and S. I. Shah, “Synthesis and antibacterial properties of silver nanoparticles,” Journal of Nanoscience and Nanotechnology, vol. 5, no. 2, pp. 244–249, 2005. View at Publisher · View at Google Scholar
  15. D. F. Emerich and C. G. Thanos, “Nanotechnology and medicine,” Expert Opinion on Biological Therapy, vol. 3, no. 4, pp. 655–663, 2003. View at Publisher · View at Google Scholar
  16. R. Lamerichs, T. Schäffter, Y. Hämisch, and J. Powers, “Molecular imaging: the road to better healthcare,” MedicaMundi, vol. 47, no. 1, pp. 2–9, 2003. View at Google Scholar
  17. European Science Foundation, “Nanomedicine—An ESF—European Medical Research Councils (EMRC) forward look report,” European Science Foundation, Strasbourg, France, 2005, http://www.esf.org/research-areas/medical-sciences/publications.html.
  18. Health Council of the Netherlands, “Neonatale screening,” The Hague: Health Council of the Netherlands, November 2005.
  19. P. Alivisatos, “The use of nanocrystals in biological detection,” Nature Biotechnology, vol. 22, no. 1, pp. 47–52, 2004. View at Publisher · View at Google Scholar
  20. C. Kimchi-Sarfaty, J. M. Oh, I.-W. Kim et al., “A “silent“ polymorphism in the MDR1 gene changes substrate specificity,” Science, vol. 315, no. 5811, pp. 525–528, 2007. View at Publisher · View at Google Scholar
  21. P. Galvin, “A nanobiotechnology roadmap for high-throughput single nucleotide polymorphism analysis,” Psychiatric Genetics, vol. 12, no. 2, pp. 75–82, 2002. View at Publisher · View at Google Scholar
  22. J. J. McCarthy and R. Hilfiker, “The use of single-nucleotide polymorphism maps in pharmacogenomics,” Nature Biotechnology, vol. 18, no. 5, pp. 505–508, 2000. View at Publisher · View at Google Scholar
  23. L. J. Van't Veer, H. Dai, M. J. Van de Vijver et al., “Gene expression profiling predicts clinical outcome of breast cancer,” Nature, vol. 415, no. 6871, pp. 530–536, 2002. View at Publisher · View at Google Scholar
  24. M. J. Van de Vijver, Y. D. He, L. J. Van 't Veer et al., “A gene-expression signature as a predictor of survival in breast cancer,” The New England Journal of Medicine, vol. 347, no. 25, pp. 1999–2009, 2002. View at Publisher · View at Google Scholar
  25. P. J. M. Valk, R. G. W. Verhaak, M. A. Beijen et al., “Prognostically useful gene-expression profiles in acute myeloid leukemia,” The New England Journal of Medicine, vol. 350, no. 16, pp. 1617–1628, 2004. View at Publisher · View at Google Scholar
  26. B. Lowenberg, H. R. Delwel, and P. J. M. Valk, “The diagnosis of acute myeloid leukaemia enhanced by using DNA microarrays,” Nederlands Tijdschrift voor Geneeskunde, vol. 149, no. 12, pp. 623–625, 2005. View at Google Scholar
  27. P. Roepman, L. F. A. Wessels, N. Kettelarij et al., “An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas,” Nature Genetics, vol. 37, no. 2, pp. 182–186, 2005. View at Publisher · View at Google Scholar
  28. M. J. Heller, A. H. Forster, and E. Tu, “Active microelectronic chip devices which utilize controlled electrophoretic fields for multiplex DNA hybridization and other genomic applications,” Electrophoresis, vol. 21, no. 1, pp. 157–164, 2000. View at Google Scholar
  29. J.-M. Laval, P.-E. Mazeran, and D. Thomas, “Nanobiotechnology and its role in the development of new analytical devices,” Analyst, vol. 125, no. 1, pp. 29–33, 2000. View at Publisher · View at Google Scholar
  30. T. Vo-Dinh, B. M. Cullum, and D. L. Stokes, “Nanosensors and biochips: frontiers in biomolecular diagnostics,” Sensors and Actuators B, vol. 74, no. 1–3, pp. 2–11, 2001. View at Publisher · View at Google Scholar
  31. G. Guetens, K. Van Cauwenberghe, G. De Boeck et al., “Nanotechnology in bio/clinical analysis,” Journal of Chromatography B, vol. 739, no. 1, pp. 139–150, 2000. View at Publisher · View at Google Scholar
  32. M. Han, X. Gao, J. Z. Su, and S. Nie, “Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules,” Nature Biotechnology, vol. 19, no. 7, pp. 631–635, 2001. View at Publisher · View at Google Scholar
  33. H. Xu, M. Y. Sha, E. Y. Wong et al., “Multiplexed SNP genotyping using the Qbead system: a quantum dot-encoded microsphere-based assay,” Nucleic Acids Research, vol. 31, no. 8, article e43, 2003. View at Google Scholar
  34. D. A. LaVan, D. M. Lynn, and R. Langer, “Moving smaller in drug discovery and delivery,” Nature Reviews Drug Discovery, vol. 1, no. 1, pp. 77–84, 2002. View at Google Scholar
  35. S. Howorka, S. Cheley, and H. Bayley, “Sequence-specific detection of individual DNA strands using engineered nanopores,” Nature Biotechnology, vol. 19, no. 7, pp. 636–639, 2001. View at Publisher · View at Google Scholar
  36. G. Wu, R. H. Datar, K. M. Hansen, T. Thundat, R. J. Cote, and A. Majumdar, “Bioassay of prostate-specific antigen (PSA) using microcantilevers,” Nature Biotechnology, vol. 19, no. 9, pp. 856–860, 2001. View at Publisher · View at Google Scholar
  37. A. Majumdar, “Bioassays based on molecular nanomechanics,” Disease Markers, vol. 18, no. 4, pp. 167–174, 2002. View at Google Scholar
  38. F. Patolsky, G. Zheng, O. Hayden, M. Lakadamyali, X. Zhuang, and C. M. Lieber, “Electrical detection of single viruses,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 39, pp. 14017–14022, 2004. View at Publisher · View at Google Scholar
  39. M. Larkin, “Nanowires show potential as virus detectors,” The Lancet Infectious Diseases, vol. 4, no. 11, p. 656, 2004. View at Google Scholar
  40. R. J. Chen, S. Bangsaruntip, K. A. Drouvalakis et al., “Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 9, pp. 4984–4989, 2003. View at Publisher · View at Google Scholar
  41. A. K. Deisingh and M. Thompson, “Biosensors for the detection of bacteria,” Canadian Journal of Microbiology, vol. 50, no. 2, pp. 69–77, 2004. View at Publisher · View at Google Scholar
  42. J. G. E. Gardeniers and A. Van den Berg, “Lab-on-a-chip systems for biomedical and environmental monitoring,” Analytical and Bioanalytical Chemistry, vol. 378, no. 7, pp. 1700–1703, 2004. View at Publisher · View at Google Scholar
  43. E. X. Vrouwe, R. Luttge, and A. van den Berg, “Direct measurement of lithium in whole blood using microchip capillary electrophoresis with integrated conductivity detection,” Electrophoresis, vol. 25, no. 10-11, pp. 1660–1667, 2004. View at Google Scholar
  44. S. M. Buck, Y.-E. L. Koo, E. Park et al., “Optochemical nanosensor PEBBLEs: photonic explorers for bioanalysis with biologically localized embedding,” Current Opinion in Chemical Biology, vol. 8, no. 5, pp. 540–546, 2004. View at Publisher · View at Google Scholar
  45. J. P. Sumner, J. W. Aylott, E. Monson, and R. Kopelman, “A fluorescent PEBBLE nanosensor for intracellular free zinc,” Analyst, vol. 127, no. 1, pp. 11–16, 2002. View at Publisher · View at Google Scholar
  46. G. M. Lanza, R. Lamerichs, S. Caruthers, and S. A. Wickline, “Molecular imaging in MR with targeted paramagnetic nanoparticles,” MedicaMundi, vol. 47, no. 1, pp. 34–39, 2003. View at Google Scholar
  47. K. C. P. Li, S. D. Pandit, S. Guccione, and M. D. Bednarski, “Molecular imaging applications in nanomedicine,” Biomedical Microdevices, vol. 6, no. 2, pp. 113–116, 2004. View at Publisher · View at Google Scholar
  48. S. K. Sahoo and V. Labhasetwar, “Nanotech approaches to drug delivery and imaging,” Drug Discovery Today, vol. 8, no. 24, pp. 1112–1120, 2003. View at Publisher · View at Google Scholar
  49. S. A. Wickline and G. M. Lanza, “Nanotechnology for molecular imaging and targeted therapy,” Circulation, vol. 107, no. 8, pp. 1092–1095, 2003. View at Publisher · View at Google Scholar
  50. P. A. Dayton and K. W. Ferrara, “Targeted imaging using ultrasound,” Journal of Magnetic Resonance Imaging, vol. 16, no. 4, pp. 362–377, 2002. View at Publisher · View at Google Scholar
  51. A. M. Morawski, P. M. Winter, K. C. Crowder et al., “Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI,” Magnetic Resonance in Medicine, vol. 51, no. 3, pp. 480–486, 2004. View at Publisher · View at Google Scholar
  52. R. Weissleder, G. Elizondo, J. Wittenberg, C. A. Rabito, H. H. Bengele, and L. Josephson, “Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging,” Radiology, vol. 175, no. 2, pp. 489–493, 1990. View at Google Scholar
  53. A. Jordan, “Nanotechnology and consequences for surgical oncology,” Kongressband Deutsche Gesellschaft fur Chirurgie Kongress, vol. 119, pp. 821–828, 2002. View at Google Scholar
  54. M. Torabi, S. L. Aquino, and M. G. Harisinghani, “Current concepts in lymph node imaging,” Journal of Nuclear Medicine, vol. 45, no. 9, pp. 1509–1518, 2004. View at Google Scholar
  55. J. W. M. Bulte, T. Douglas, B. Witwer et al., “Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells,” Nature Biotechnology, vol. 19, no. 12, pp. 1141–1147, 2001. View at Publisher · View at Google Scholar
  56. S. Svenson and D. . Tomalia, “Dendrimers in biomedical applications—reflections on the field,” Advanced Drug Delivery Reviews, vol. 57, no. 15, pp. 2106–2129, 2005. View at Publisher · View at Google Scholar
  57. H. Kobayashi and M. W. Brechbiel, “Dendrimer-based nanosized MRI contrast agents,” Current Pharmaceutical Biotechnology, vol. 5, no. 6, pp. 539–549, 2004. View at Publisher · View at Google Scholar
  58. H. Kobayashi and M. W. Brechbiel, “Nano-sized MRI contrast agents with dendrimer cores,” Advanced Drug Delivery Reviews, vol. 57, no. 15, pp. 2271–2286, 2005. View at Publisher · View at Google Scholar
  59. M. Bruchez Jr., M. Moronne, P. Gin, S. Weiss, and A. P. Alivisatos, “Semiconductor nanocrystals as fluorescent biological labels,” Science, vol. 281, no. 5385, pp. 2013–2016, 1998. View at Publisher · View at Google Scholar
  60. W. J. Parak, T. Pellegrino, and C. Plank, “Labelling of cells with quantum dots,” Nanotechnology, vol. 16, no. 2, pp. R9–R25, 2005. View at Publisher · View at Google Scholar
  61. T. M. Jovin, “Quantum dots finally come of age,” Nature Biotechnology, vol. 21, no. 1, pp. 32–33, 2003. View at Publisher · View at Google Scholar
  62. D. S. Lidke and D. J. Arndt-Jovin, “Imaging takes a quantum leap,” Physiology, vol. 19, no. 6, pp. 322–325, 2004. View at Google Scholar
  63. X. Michalet, F. F. Pinaud, L. A. Bentolila et al., “Quantum dots for live cells, in vivo imaging, and diagnostics,” Science, vol. 307, no. 5709, pp. 538–544, 2005. View at Publisher · View at Google Scholar
  64. X. Wu, H. Liu, J. Liu et al., “Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots,” Nature Biotechnology, vol. 21, no. 1, pp. 41–46, 2003. View at Publisher · View at Google Scholar
  65. B. Dubertret, P. Skourides, D. J. Norris, V. Noireaux, A. H. Brivanlou, and A. Libchaber, “In vivo imaging of quantum dots encapsulated in phospholipid micelles,” Science, vol. 298, no. 5599, pp. 1759–1762, 2002. View at Publisher · View at Google Scholar
  66. R. F. Uren, “Cancer surgery joins the dots,” Nature Biotechnology, vol. 22, no. 1, pp. 38–39, 2004. View at Publisher · View at Google Scholar
  67. S. Kim, Y. T. Lim, E. G. Soltesz et al., “Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping,” Nature Biotechnology, vol. 22, no. 1, pp. 93–97, 2004. View at Publisher · View at Google Scholar
  68. S. Shrivastava, “Nanomedicines: physiological principals of distribution,” DJNB, vol. 3, no. 4, pp. 303–308, 2008. View at Google Scholar
  69. T. M. Allen and P. R. Cullis, “Drug delivery systems: entering the mainstream,” Science, vol. 303, no. 5665, pp. 1818–1822, 2004. View at Publisher · View at Google Scholar
  70. R. Langer, “Drug delivery and targeting,” Nature, vol. 392, no. 6679, pp. 5–10, 1998. View at Google Scholar
  71. C.-K. Kim and S.-J. Lim, “Recent progress in drug delivery systems for anticancer agents,” Archives of Pharmacal Research, vol. 25, no. 3, pp. 229–239, 2002. View at Google Scholar
  72. D. J. A. Crommelin, G. Storm, W. Jiskoot, R. Stenekes, E. Mastrobattista, and W. E. Hennink, “Nanotechnological approaches for the delivery of macromolecules,” Journal of Controlled Release, vol. 87, no. 1–3, pp. 81–88, 2003. View at Publisher · View at Google Scholar
  73. R. H. Müller and C. M. Keck, “Challenges and solutions for the delivery of biotech drugs—a review of drug nanocrystal technology and lipid nanoparticles,” Journal of Biotechnology, vol. 113, no. 1–3, pp. 151–170, 2004. View at Publisher · View at Google Scholar
  74. A. A. Gabizon, “Stealth liposomes and tumor targeting: one step further in the quest for the magic bullet,” Clinical Cancer Research, vol. 7, no. 2, pp. 223–225, 2001. View at Google Scholar
  75. D. E. Owens III and N. A. Peppas, “Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles,” International Journal of Pharmaceutics, vol. 307, no. 1, pp. 93–102, 2006. View at Publisher · View at Google Scholar
  76. D. Akin, J. Sturgis, K. Ragheb et al., “Bacteria-mediated delivery of nanoparticles and cargo into cells,” Nature Nanotechnology, vol. 2, no. 7, pp. 441–449, 2007. View at Publisher · View at Google Scholar
  77. Y. Matsumura and H. Maeda, “A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs,” Cancer Research, vol. 46, no. 12, pp. 6387–6392, 1986. View at Google Scholar
  78. S. M. Moghimi, A. C. Hunter, and J. C. Murray, “Long-circulating and target-specific nanoparticles: theory to practice,” Pharmacological Reviews, vol. 53, no. 2, pp. 283–318, 2001. View at Google Scholar
  79. G. Xu, K.-T. Yong, I. Roy et al., “Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier,” Bioconjugate Chemistry, vol. 19, no. 6, pp. 1179–1185, 2008. View at Publisher · View at Google Scholar
  80. R. H. Müller and C. M. Keck, “Drug delivery to the brain-realization by novel drug carriers,” Journal of Nanoscience and Nanotechnology, vol. 4, no. 5, pp. 471–483, 2004. View at Publisher · View at Google Scholar
  81. K.-T. Yong, J. Qian, I. Roy et al., “Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells,” Nano Letters, vol. 7, no. 3, pp. 761–765, 2007. View at Publisher · View at Google Scholar
  82. A. Quintana, E. Raczka, L. Piehler et al., “Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor,” Pharmaceutical Research, vol. 19, no. 9, pp. 1310–1316, 2002. View at Publisher · View at Google Scholar
  83. M.-S. Hong, S.-J. Lim, Y.-K. Oh, and C.-K. Kim, “pH-sensitive, serum-stable and long-circulating liposomes as a new drug delivery system,” Journal of Pharmacy and Pharmacology, vol. 54, no. 1, pp. 51–58, 2002. View at Publisher · View at Google Scholar
  84. A. S. Lubbe, C. Bergemann, H. Riess et al., “Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors,” Cancer Research, vol. 56, no. 20, pp. 4686–4693, 1996. View at Google Scholar
  85. C. Alexiou, R. Jurgons, R. J. Schmid et al., “Magnetic drug targeting-biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment,” Journal of Drug Targeting, vol. 11, no. 3, pp. 139–149, 2003. View at Publisher · View at Google Scholar
  86. Z. M. Saiyed, S. D. Telang, and C. N. Ramchand, “Application of magnetic techniques in the field of drug discovery and biomedicine,” BioMagnetic Research and Technology, vol. 1, pp. 1–8, 2003. View at Publisher · View at Google Scholar
  87. B. Radt, T. A. Smith, and F. Caruso, “Optically addressable nanostructured capsules,” Advanced Materials, vol. 16, no. 23-24, pp. 2184–2189, 2004. View at Publisher · View at Google Scholar
  88. J. L. Nelson, B. L. Roeder, J. C. Carmen, F. Roloff, and W. G. Pitt, “Ultrasonically activated chemotherapeutic drug delivery in a rat model,” Cancer Research, vol. 62, no. 24, pp. 7280–7283, 2002. View at Google Scholar
  89. G. Kong, R. D. Braun, and M. W. Dewhirst, “Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature,” Cancer Research, vol. 61, no. 7, pp. 3027–3032, 2001. View at Google Scholar
  90. D. E. Meyer, B. C. Shin, G. A. Kong, M. W. Dewhirst, and A. Chilkoti, “Drug targeting using thermally responsive polymers and local hyperthermia,” Journal of Controlled Release, vol. 74, no. 1–3, pp. 213–224, 2001. View at Publisher · View at Google Scholar
  91. D. E. Meyer, G. A. Kong, M. W. Dewhirst, M. R. Zalutsky, and A. Chilkoti, “Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia,” Cancer Research, vol. 61, no. 4, pp. 1548–1554, 2001. View at Google Scholar
  92. K. J. Widder, A. E. Senyei, and D. G. Scarpelli, “Magnetic microspheres: a model system for site specific drug delivery in vivo,” Proceedings of the Society for Experimental Biology and Medicine, vol. 158, no. 2, pp. 141–146, 1978. View at Google Scholar
  93. K. J. Widder, A. E. Senyei, and D. F. Ranney, “Magnetically responsive microspheres and other carriers for the biophysical targeting of antitumor agents,” Advances in Pharmacology and Chemotherapy, vol. 16, pp. 213–271, 1979. View at Google Scholar
  94. C. Alexiou, W. Arnold, R. J. Klein et al., “Locoregional cancer treatment with magnetic drug targeting,” Cancer Research, vol. 60, no. 23, pp. 6641–6648, 2000. View at Google Scholar
  95. A. S. Lubbe, C. Alexiou, and C. Bergemann, “Clinical applications of magnetic drug targeting,” Journal of Surgical Research, vol. 95, no. 2, pp. 200–206, 2001. View at Publisher · View at Google Scholar
  96. J. Koda, A. Venook, E. Walser et al., “Phase I/II trial of hepatic intraarterial delivery of doxorubicin hydrochloride adsorbed to magnetic targeted carriers in patients with hepatocarcinoma,” European Journal of Cancer, vol. 38, supplement 7, p. S18, 2002. View at Google Scholar
  97. M. W. Wilson, R. K. Kerlan Jr., N. A. Fidelman et al., “Reginoal therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/conventional angiography suite-initial experience with 4 patients,” Radiology, vol. 230, no. 1, pp. 287–293, 2004. View at Publisher · View at Google Scholar
  98. L. R. Hirsch, R. J. Stafford, J. A. Bankson et al., “Nanoshell-mediated nearinfrared thermal therapy of tumors under magnetic resonance guidance,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 23, pp. 13549–13554, 2003. View at Google Scholar
  99. D. P. O'Neal, L. R. Hirsch, N. J. Halas, J. D. Payne, and J. L. West, “Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles,” Cancer Letters, vol. 209, no. 2, pp. 171–176, 2004. View at Publisher · View at Google Scholar
  100. M. Johannsen, B. Thiesen, A. Jordan et al., “Magnetic fluid hyperthermia (MFH) reduces prostate cancer growth in the orthotopic Dunning R3327 rat model,” Prostate, vol. 64, no. 3, pp. 283–292, 2005. View at Publisher · View at Google Scholar
  101. A. Joshi, S. Punyani, S. S. Bale, H. Yang, T. Borca-Tasciuc, and R. S. Kane, “Nanotube-assisted protein deactivation,” Nature Nanotechnology, vol. 3, no. 1, pp. 41–45, 2008. View at Publisher · View at Google Scholar
  102. A. A. Bhirde, V. Patel, J. Gavard et al., “Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery,” ACS Nano, vol. 3, no. 2, pp. 307–316, 2009. View at Publisher · View at Google Scholar
  103. N. W. S. Kam, M. O'Connell, J. A. Wisdom, and H. Dai, “Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 33, pp. 11600–11605, 2005. View at Publisher · View at Google Scholar
  104. I. Hilger, R. Hergt, and W. A. Kaiser, “Use of magnetic nanoparticle heating in the treatment of breast cancer,” IEE Proceedings Nanobiotechnology, vol. 152, no. 1, pp. 33–39, 2005. View at Publisher · View at Google Scholar
  105. R. Hergt, S. Dutz, R. Müller, and M. Zeisberger, “Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy,” Journal of Physics Condensed Matter, vol. 18, no. 38, pp. S2919–S2934, 2006. View at Publisher · View at Google Scholar
  106. P. Moroz, S. K. Jones, and B. N. Gray, “Magnetically mediated hyperthermia: current status and future directions,” International Journal of Hyperthermia, vol. 18, no. 4, pp. 267–284, 2002. View at Publisher · View at Google Scholar
  107. R. W. Rand, H. D. Snow, D. G. Elliott, and G. M. Haskins, “Induction heating method for use in causing necrosis of neoplasm,” US patent specification, 1985.
  108. S. Shrivastava, T. Bera, S. K. Singh, G. Singh, P. Ramachandrarao, and D. Dash, “Characterization of antiplatelet properties of silver nanoparticles,” ACS Nano, vol. 3, no. 6, pp. 1357–1364, 2009. View at Publisher · View at Google Scholar
  109. G. E. Park and T. J. Webster, “A review of nanotechnology for the development of better orthopedic implants,” Journal of Biomedical Nanotechnology, vol. 1, no. 1, pp. 18–29, 2005. View at Google Scholar
  110. S. A. Catledge, M. D. Fries, Y. K. Vohra et al., “Nanostructured ceramics for biomedical implants,” Journal of Nanoscience and Nanotechnology, vol. 2, no. 3-4, pp. 293–312, 2002. View at Publisher · View at Google Scholar
  111. T. J. Webster, R. W. Siegel, and R. Bizios, “Osteoblast adhesion on nanophase ceramics,” Biomaterials, vol. 20, no. 13, pp. 1221–1227, 1999. View at Publisher · View at Google Scholar
  112. T. J. Webster and J. U. Ejiofor, “Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo,” Biomaterials, vol. 25, no. 19, pp. 4731–4739, 2004. View at Publisher · View at Google Scholar
  113. T. J. Webster, E. L. Hellenmeyer, and R. L. Price, “Increased osteoblast functions on theta+delta nanofiber alumina,” Biomaterials, vol. 26, no. 9, pp. 953–960, 2005. View at Publisher · View at Google Scholar
  114. K. M. Woo, V. J. Chen, and P. X. Ma, “Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment,” Journal of Biomedical Materials Research Part A, vol. 67, no. 2, pp. 531–537, 2003. View at Google Scholar
  115. R. L. Price, K. M. Haberstroh, and T. J. Webster, “Enhanced functions of osteoblasts on nanostructed surfaces of carbon and alumina,” Medical and Biological Engineering and Computing, vol. 41, no. 3, pp. 372–375, 2003. View at Publisher · View at Google Scholar
  116. O. V. Salata, “Applications of nanoparticles in biology and medicine,” Journal of Nanobiotechnology, vol. 2, no. 1, pp. 3–8, 2004. View at Publisher · View at Google Scholar
  117. F. Heidenau, W. Mittelmeier, R. Detsch et al., “A novel antibacterial titania coating: metal ion toxicity and in vitro surface colonization,” Journal of Materials Science: Materials in Medicine, vol. 16, no. 10, pp. 883–888, 2005. View at Publisher · View at Google Scholar
  118. R. L. Price, M. C. Waid, K. M. Haberstroh, and T. J. Webster, “Selective bone cell adhesion on formulations containing carbon nanofibers,” Biomaterials, vol. 24, no. 11, pp. 1877–1887, 2003. View at Publisher · View at Google Scholar
  119. S. Kay, A. Thapa, K. M. Haberstroh, and T. J. Webster, “Nanostructured polymer/nanophase ceramic composites enhance osteoblast and chondrocyte adhesion,” Tissue Engineering, vol. 8, no. 5, pp. 753–761, 2002. View at Publisher · View at Google Scholar
  120. B. Zhao, H. Hu, S. K. Mandal, and R. C. Haddon, “A bone mimic based on the self-assembly of hydroxyapatite on chemically functionalized single-walled carbon nanotubes,” Chemistry of Materials, vol. 17, no. 12, pp. 3235–3241, 2005. View at Publisher · View at Google Scholar
  121. R. Vasita and D. S. Katti, “Nanofibers and their applications in tissue engineering,” International Journal of Nanomedicine, vol. 1, no. 1, pp. 15–30, 2006. View at Publisher · View at Google Scholar
  122. R. G. Ellis-Behnke, Y.-X. Liang, S.-W. You et al., “Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 13, pp. 5054–5059, 2006. View at Publisher · View at Google Scholar
  123. N. Huang, P. Yang, Y. X. Leng et al., “Hemocompatibility of titanium oxide films,” Biomaterials, vol. 24, no. 13, pp. 2177–2187, 2003. View at Publisher · View at Google Scholar
  124. J. T. Santini Jr., M. J. Cima, and R. Langer, “A controlled-release microchip,” Nature, vol. 397, no. 6717, pp. 335–338, 1999. View at Publisher · View at Google Scholar
  125. J. T. Santini Jr., A. C. Richards, R. A. Scheidt, M. J. Cima, and R. S. Langer, “Microchip technology in drug delivery,” Annals of Medicine, vol. 32, no. 6, pp. 377–379, 2000. View at Google Scholar
  126. D. A. LaVan, T. McGuire, and R. Langer, “Small-scale systems for in vivo drug delivery,” Nature Biotechnology, vol. 21, no. 10, pp. 1184–1191, 2003. View at Publisher · View at Google Scholar
  127. E. Zrenner, “Will retinal implants restore vision?” Science, vol. 295, no. 5557, pp. 1022–1025, 2002. View at Publisher · View at Google Scholar
  128. M. A. L. Nicolelis, “Actions from thoughts,” Nature, vol. 409, no. 6818, pp. 403–407, 2001. View at Publisher · View at Google Scholar
  129. M. A. L. Nicolelis, “Brain-machine interfaces to restore motor function and probe neural circuits,” Nature Reviews Neuroscience, vol. 4, no. 5, pp. 417–422, 2003. View at Publisher · View at Google Scholar
  130. M. A. L. Nicolelis and J. K. Chapin, “Controlling Roberts with the mind,” Scientific American, vol. 287, no. 4, p. 46, 2002. View at Google Scholar
  131. M. D. Serruya, N. G. Hatsopoulos, L. Paninski, M. R. Fellows, and J. P. Donoghue, “Instant neural control of a movement signal,” Nature, vol. 416, no. 6877, pp. 141–142, 2002. View at Publisher · View at Google Scholar
  132. J. P. Donoghue, “Connecting cortex to machines: recent advances in brain interfaces,” Nature Neuroscience, vol. 5, supplement, pp. 1085–1088, 2002. View at Publisher · View at Google Scholar
  133. A. B. Schwartz, “Cortical neural prosthetics,” Annual Review of Neuroscience, vol. 27, pp. 487–507, 2004. View at Publisher · View at Google Scholar
  134. P. R. Kennedy, R. A. E. Bakay, M. M. Moore, K. Adams, and J. Goldwaithe, “Direct control of a computer from the human central nervous system,” IEEE Transactions on Rehabilitation Engineering, vol. 8, no. 2, pp. 198–202, 2000. View at Publisher · View at Google Scholar
  135. Press report of Brown University, “Pilot study of mind-to-movement device shows early promise,” July 2008, http://www.news-medical.net/news/2004/10/10/5440.aspx.
  136. M. A. L. Nicolelis, “The amazing adventures of robotrat,” Trends in Cognitive Sciences, vol. 6, no. 11, pp. 449–450, 2002. View at Publisher · View at Google Scholar
  137. S. K. Talwar, S. Xu, E. S. Hawley, S. A. Weiss, K. A. Moxon, and J. K. Chapin, “Rat navigation guided by remote control,” Nature, vol. 417, no. 6884, pp. 37–38, 2002. View at Publisher · View at Google Scholar
  138. T. Stieglitz, “Considerations on surface and structural biocompatibility as prerequisite for long-term stability of neural prostheses,” Journal of Nanoscience and Nanotechnology, vol. 4, no. 5, pp. 496–503, 2004. View at Publisher · View at Google Scholar
  139. S. Raghava, G. Goel, and U. B. Kompella, “Ophthalmic applications of nanotechnology,” in Ocular Transporters in Ophthalmic Diseases and Drug Delivery, J. T. Tink and C. J. Barnstable, Eds., vol. 7, pp. 415–435, Humana Press, Totowa, NJ, USA, 2008. View at Publisher · View at Google Scholar
  140. K. A. Moxon, N. M. Kalkhoran, M. Markert, M. A. Sambito, J.L. McKenzie, and J. T. Webster, “Nanostructured surface modification of ceramic-based microelectrodes to enhance biocompatibility for a direct brain-machine interface,” IEEE Transactions on Biomedical Engineering, vol. 51, no. 6, pp. 881–889, 2004. View at Publisher · View at Google Scholar
  141. M. Arruebo, R. Fernandez-Pacheco, M. R. Ibarra, and J. Santamaria, “Magnetic nanoparticles for drug delivery,” Nano Today, vol. 2, no. 3, pp. 22–32, 2007. View at Publisher · View at Google Scholar
  142. M. Morrison, “Nanotechnology and its implications for the health of the EU citizen,” Nanoforum, 2003, http://www.nanoforum.org/dateien/temp/Nanotechnology%20and%20its%20Implication%20for%20the%20Health%20of%20the%20EU%20Citizen%20(18.12.03).pdf?01072004120631.
  143. S. L. Tao and T. A. Desai, “Microfabricated drug delivery systems: from particles to pores,” Advanced Drug Delivery Reviews, vol. 55, no. 3, pp. 315–328, 2003. View at Publisher · View at Google Scholar
  144. B. Scrosati, “Nanomaterials: paper powers battery breakthrough,” Nature Nanotechnology, vol. 2, no. 10, pp. 598–599, 2007. View at Publisher · View at Google Scholar
  145. A. B. Lansdown, “Silver. I: its antibacterial properties and mechanism of action,” Journal of Wound Care, vol. 11, no. 4, pp. 125–130, 2002. View at Google Scholar
  146. F. Furno, K. S. Morley, B. Wong et al., “Silver nanoparticles and polymeric medical devices: a new approach to prevention of infection?” Journal of Antimicrobial Chemotherapy, vol. 54, no. 6, pp. 1019–1024, 2004. View at Publisher · View at Google Scholar
  147. S. Shrivastava, “Nanofabrication for drug delivery and tissue engineering,” Digest Journal of Nanomaterials and Biostructures, vol. 3, no. 4, pp. 257–263, 2008. View at Google Scholar
  148. U. Samuel and J. P. Guggenbichler, “Prevention of catheter-related infections: the potential of a new nano-silver impregnated catheter,” International Journal of Antimicrobial Agents, vol. 23, supplement 1, pp. S75–S78, 2004. View at Publisher · View at Google Scholar
  149. V. Alt, T. Bechert, P. Steinrucke et al., “Nanoparticulate silver. A new antimicrobial substance for bone cement,” Orthopade, vol. 33, no. 8, pp. 885–892, 2004. View at Google Scholar
  150. V. Alt, T. Bechert, P. Steinrucke et al., “An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement,” Biomaterials, vol. 25, no. 18, pp. 4383–4391, 2004. View at Publisher · View at Google Scholar
  151. A. B. Lansdown, “A guide to the properties and uses of silver dressings in wound care,” Professional Nurse, vol. 20, no. 5, pp. 41–43, 2005. View at Google Scholar
  152. P.-C. Maness, S. Smolinski, D. M. Blake, Z. Huang, E. J. Wolfrum, and W. A. Jacoby, “Bactericidal activity of photocatalytic TiO2 reaction: toward an understanding of its killing mechanism,” Applied and Environmental Microbiology, vol. 65, no. 9, pp. 4094–4098, 1999. View at Google Scholar
  153. Y. Kai, Y. Komazawa, A. Miyajima, N. Miyata, and Y. Yamakoshi, “[60]Fullerene as a novel photoinduced antibiotic,” Fullerenes Nanotubes and Carbon Nanostructures, vol. 11, no. 1, pp. 79–87, 2003. View at Publisher · View at Google Scholar
  154. R. Holladay, W. Moeller, D. Mehta, J. Brooks, R. Roy, and M. Mortenson, “Silver/water, silver gels and silver-based compositions, and methods for making and using the same,” Application Number WO2005US47699 20051230 European Patent Office, 2006.
  155. “Radio-frequency identification: its potential in healthcare,” Health Devices, vol. 34, no. 5, pp. 149–160, 2005.
  156. P. N. Valenstein and R. L. Sirota, “Identification errors in pathology and laboratory medicine,” Clinics in Laboratory Medicine, vol. 24, no. 4, pp. 979–996, 2004. View at Publisher · View at Google Scholar
  157. W. S. Sandberg, M. Hakkinen, M. Egan et al., “Automatic detection and notification of “wrong patient-wrong location” errors in the operating room,” Surgical Innovation, vol. 12, no. 3, pp. 253–260, 2005. View at Publisher · View at Google Scholar
  158. N. Ahrens, A. Pruss, H. Kiesewetter, and A. Salama, “Failure of bedside ABO testing is still the most common cause of incorrect blood transfusion in the Barcode era,” Transfusion and Apheresis Science, vol. 33, no. 1, pp. 25–29, 2005. View at Publisher · View at Google Scholar
  159. H. J. Meyer, N. Chansue, and F. Monticelli, “Implantation of radio frequency identification device (RFID) microchip in disaster victim identification (DVI),” Forensic Science International, vol. 157, no. 2-3, pp. 168–171, 2006. View at Publisher · View at Google Scholar
  160. S. Shrivastava and D. Dash, “Agrifood nanotechnology: a tiny revolution in food and agriculture,” Journal of Nano Research. In press.