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Journal of Nanotechnology
Volume 2009 (2009), Article ID 238536, 6 pages
http://dx.doi.org/10.1155/2009/238536
Research Article

Drug-Carrying Magnetic Nanocomposite Particles for Potential Drug Delivery Systems

1Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
2Department of Bioengineering, University of KS, Lawrence, KS, USA
3Institute of Physics, Academia Sinica, Taipei, Taiwan
4Department of Basic Engineering Science, Menoufiya University, Shebin, Egypt
5Department of Physics, Wichita State University, Wichita, KS, USA

Received 10 May 2009; Accepted 5 August 2009

Academic Editor: Sakhrat Khizroev

Copyright © 2009 R. Asmatulu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Drug-carrying magnetic nanocomposite spheres were synthesized using magnetite nanoparticles and poly (D,L-lactide-co-glycolide) (PLGA) for the purpose of magnetic targeted drug delivery. Magnetic nanoparticles ( 13 nm on average) of magnetite were prepared by a chemical coprecipitation of ferric and ferrous chloride salts in the presence of a strong basic solution (ammonium hydroxide). An oil-in-oil emulsion/solvent evaporation technique was conducted at 7000 rpm and 1.5–2 hours agitation for the synthesis of nanocomposite spheres. Specifically, PLGA and drug were first dissolved in acetonitrile (oily phase I) and combined with magnetic nanoparticles, then added dropwise into viscous paraffin oil combined with Span 80 (oily phase II). With different contents (0%, 10%, 20%, and 25%) of magnetite, the nanocomposite spheres were evaluated in terms of particle size, morphology, and magnetic properties by using dynamic laser light scattering (DLLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and a superconducting quantum interference device (SQUID). The results indicate that nanocomposite spheres (200 nm to 1.1  m in diameter) are superparamagnetic above the blocking temperature near 40 K and their magnetization saturates above 5 000 Oe at room temperature.