Cyclosporine A Loaded PLGA Nanoparticles for Dry Eye Disease: In Vitro Characterization Studies

Table 4

Particle size, PDI of CsA loaded NPs after and before freeze drying (FD) and production yield of NPs.

NPs code	Particle size before FD (nm)	Polydispersity index (PDI) before FD	Particle size after FD (nm)	Polydispersity index (PDI) after FD	Production yeild
F1	160.0 ± 08	0.395±0.061	161.20 ± 10	0.640 ± 0.053	52.29 ± 2.4
F2	182.98 ± 13	0.265 ± 0.084	204.30 ± 12	0.460 ± 0.081	55.72 ± 3.1
F3	130.5 ± 10	0.105 ± 0.042	145.5 ± 12	0.262 ± 0.054	85.30 ± 2.1
F4	128.48 ± 13	0.388 ± 0.060	145.7 ± 13	0.582 ± 0.065	64.90 ± 3.0
F5	144.53 ± 13	0.208 ± 0.045	170.5 ± 14.5	0.508 ± 0.051	80.45 ± 2.6
F6	210.75 ± 16	0.458 ± 0.043	226.3 ± 18	0.655 ± 0.048	81.90 ± 1.9
F7	235.2 ± 19.5	0.198 ± 0.058	244.1 ± 23	0.669 ± 0.063	56.87 ± 2.8
F8	240.68 ± 22	0.410 ± 0.063	258.3 ± 24.5	0.620 ± 0.058	80.39 ± 2.5
F9	253.50 ± 18	0.404 ± 0.057	260.0 ± 26	0.474 ± 0.066	83.40 ± 2.8

Data as mean ± SD, 𝑛=3, *FD: Freeze drying.