Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats

Table 1

Pharmacokinetic parameters for AZT solution and AZT-SLNs formulation.

Parameters	AZT solution; (mean ± SD)	AZT-SLNs; (mean ± SD)
𝐶max (ng/mL)	6464.21±1149.076	3992.21±223.8821
𝑇max (min)	15.00±0.00	15.00±0.00
AUC0--𝑡 (min*ng/mL)	314306.7±70319.3	403576.3±45743.43
AUC0--∞ (min*ng/mL)	321262.7±75314.74	421676.3±52967.66
𝑡1⧵2 (min)	80.41±12.15	105.41±10.56
CL (mL/min/kg)	29.85±3.97	23.12±0.92
MRT (min)	77.01±1.74	140.56±14.75