Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method
Table 1
Solvent and nonsolvent effect on nanoparticle formation by nanoprecipitation method.
Particle size (nm)
Solvent
Dielectric constant (Ɛ)
Nonsolvent
Ethyl acetate (Ɛ = 6.0)
Methyl acetate (Ɛ = 6.7)
Acetone (Ɛ = 20.7)
DMSO (Ɛ = 48.9)
No
AE
EL
No
AE
EL
No
AE
EL
No
AE
EL
2.0
Heptane
A
PS
PS
A
PS
PS
A
PS
PS
NM
NM
NM
3.0
Neobee 1053
A
A
PS
A
AS
PS
A
A
PS
NM
NM
NM
5.0
Amyl acetate
A
A
A
A
A
A
A
A
A
NM
NM
NM
17.1
Butanol
A
A
A
A
456.3 ± 15.9
A
A
287.7 ± 5.6
A
536.4 ± 22.3
524 ± 22.2
A
32.0
Propylene glycol
A
A
A
A
A
A
A
A
A
696.8 ± 13.6
2772 ± 861
630.4 ± 7.8
No: no surfactant used; AE: Bio-Soft N1-7; EL: Stepan-Mild L3; PS: partially soluble in the nonsolvent; A: aggregation; NM: not miscible; microparticles present in the suspension.
