Research Article
Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method
Table 2
Effect of variables on particle size, entrapment efficiency, and specific load.
| | Variable | Particle size | Efficiency | Specific load |
| | Viscosity nonsolvent | = | + | + | | pH | = | = | = | | O/V volume ratio | − | − | − | | Concentration NAC solvent | = | = | + | | Concentration NAC nonsolvent | = | + | + | | Solvent | = | = | = | | Ca addition | − | = | = | | PLGA concentration | + | + | = | | PLGA molecular weight | + | = | = |
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