Plant-Mediated Green Synthesis of Ag NPs and Their Possible Applications: A Critical Review

Table 6

Operational condition during synthesis of Ag NPs and their anticancer activity on different cell lines.

Size by TEM/SEM with morphology	Operational condition	Anticancer activity
		Cell line	IC50 (μg/mL)	References
TEM 33 nm average size with spherical shape	9 : 1 ratio of 0.1 M AgNO3 and Nepeta deflersiana extract incubated for 24 hours and then continuously stirred at 90°C	HeLa	5	[179]
SEM 30–50 nm with spherical shapes	9 : 1 ratio of 1 mM AgNO3 and Cucumis prophetarum leaf extract followed by heating at 80°C for 3 hours with constant stirring	A549	105.8	[79]
		MDA-MB-231	81.1
		HepG2	94.2
		MCF-7	65.6
TEM 6.7 nm average size with spherical shape	4 : 1 ratio of 1 mM AgNO3 and Abelmoschus esculentus pulp extract at room temperature with continuous stirring for 9 hours	Jurkat cells	16.15	[180]
TEM 40–80 nm with spherical shape	3 : 10 ratio of Salacia chinensis bark extract and 1 mM AgNO3 heated at 65°C for 15 minutes	HepG2	6.31	[181]
		L-132	4.002
		MIA-Pa-Ca-2	5.22
		MDA-MB-231	8.452
		KB cells	14.37
		PC-3	7.46
		HeLa	6.55
SEM 15.6 nm average size with spherical shape	1 : 1 ratio of 6 mM AgNO3 and Punica granatum fruit extract at 37–40°C under stirring in dark for 24 hours and pH 8	BT-20	37	[182]
		MCF-7	17