Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells

Figure 2

Granzyme B in cancer targeting. Granzyme B expression is increased as CTLs mature. While CD44 is moderately expressed in the early stages of CTL maturation, its expression increases during the maturation process. A mechanism by which antigen priming with IL-2 and IL-15 increases granzyme B induction is shown. In contrast, IL-21 is shown to cause opposing effect [22].