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Journal of Oncology
Volume 2008, Article ID 626340, 6 pages
http://dx.doi.org/10.1155/2008/626340
Research Article

Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease

1Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany
2Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
3Department of Urology, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
4Institute of Surgery, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
5Interdisciplinary Translational Oncological Laboratory (ITOL), Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
6Unit of Toxicology and Chemotherapy, German Cancer Research Center, 69120 Heidelberg, Germany
7First Department of Internal Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany

Received 20 May 2008; Revised 9 September 2008; Accepted 29 September 2008

Academic Editor: Meenhard Herlyn

Copyright © 2008 Thomas C. Wehler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape. In different tumor entities, the level of chemokine receptor CXCR4 expression has been linked with tumor progression and decreased survival. The aim of this study was to evaluate the influence of CXCR4 expression on the progression of human renal cell carcinoma. CXCR4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients. Intensity of CXCR4 expression was correlated with both tumor and patient characteristics. Human renal cell carcinoma revealed variable intensities of CXCR4 expression. Strong CXCR4 expression of renal cell carcinoma was significantly associated with advanced T-status ( ), tumor dedifferentiation (P = .0005), and low hemoglobin (P = .039). In summary, strong CXCR4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.