Clinical Study
CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study
Table 1
Description of the study individuals.
| | Variable considered | Cases | Controls |
| | Age (mean, IC95%) | 55.0 (52.7–57.3) | 59.4 (57.0–61.8) |
| | Cancer location | | |
| | Oral | 53 (57.6%) | | | Pharyngeal | 39 (42.4%) | |
| | Cigarette smoking | | |
| | Never smoker | 2 (2.2%) | 49 (37.7%) | | Former smoker | 17 (18.5%) | 42 (32.3%) | | Current smoker | 73 (79.3%) | 39 (30%) |
| | Tobacco consumption (pack-years) | | |
| | Percentil 25 | 33.0 | 0 | | Percentil 50 | 46.5 | 9.9 | | Percentil 75 | 67.5 | 43.8 |
| | Drinking habit | | |
| | No alcohol drinking | 2 (2.2%) | 20 (15.4%) | | Light drinker (≤2 glasses of wine/beers or 2 licors a day) (0–280 gm/week)
| 6 (6.5%)
| 50 (38.5%)
| | Moderate drinkers (3–6 drinks/day)
(281–840 g/week) | 41 (44.6%) | 46 (35.4%)
| | Heavy drinkers (>6 drinks/day) (>840 gm/week) | 43 (46.7%) | 14 (10.8%) |
| |
Alcohol
consumption gm/week | | |
| | Percentil 25 | 290 | 70 | | Percentil 50 | 560 | 145 | | Percentil 75 | 840 | 300 |
| | CYP1A1 | | |
| | Wild type (Ile/Ile) | 64 (97%) | 90 (97.8%) | | Mutation (Ile/Val, Val/Val) | 2 (3%) | 2 (2.2%) |
| | mEH (139 ) | | |
| | Arg/Arg | 63 (68.5%) | 88 (67.7%) | | Arg/His | 25 (27.2%) | 41 (31.5%) | | His/His | 4 (4.3%) | 1 (0.8%) |
| | GSTM1 | | |
| | Present (GSTM1 +) | 45 (48.9%) | 68 (52.3%) | | Absent (GSTM1 −) | 47 (51.1%) | 62 (47.7%) |
| | Total | 92 | 130 |
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