Journal of Oncology / 2008 / Article / Tab 4

Clinical Study

CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study

Table 4

Risks for the different polymorphisms broken down by alcohol intake.

Genetic polymorphism Cases Controls OR crude OR adjusted

Light drinkers (≤280 gm alcohol/week)

CYP1A1

No mutated23431.001.00
Mutated02

mEH (139 )

His/His18641.001.00
His/Arg5310.57 (0.19–1.72)0.71 (0.22–2.24)
Arg/arg01

GSTM1

Present10521.001.00
Absent13441.55 (0.62–3.88)1.97 (0.73–5.35)

Moderate/heavy drinkers (>280 gm alcohol/week)

CYP1A1

No mutated67211.001.00
Mutated20

mEH (139 )

His/His45241.001.00
His/Arg20101.28 (0.50–3.31)0.83 (0.30–2.30)
Arg/arg40

GSTM1

Present35161.001.00
Absent34180.79 (0.34–1.86)0.69 (0.28–1.72)

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