Clinical Study
CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study
Table 4
Risks for the different polymorphisms broken down by
alcohol intake.
| | Genetic polymorphism | Cases | Controls | OR crude | OR adjusted |
| | Light drinkers (≤280 gm alcohol/week) |
| | CYP1A1 | | | | |
| | No mutated | 23 | 43 | 1.00 | 1.00 | | Mutated | 0 | 2 | — | — |
| | mEH (139) | | | | |
| | His/His | 18 | 64 | 1.00 | 1.00 | | His/Arg | 5 | 31 | 0.57 (0.19–1.72) | 0.71 (0.22–2.24) | | Arg/arg | 0 | 1 | — | — |
| | GSTM1 | | | | |
| | Present | 10 | 52 | 1.00 | 1.00 | | Absent | 13 | 44 | 1.55 (0.62–3.88) | 1.97 (0.73–5.35) |
| | Moderate/heavy
drinkers (>280 gm alcohol/week) |
| | CYP1A1 | | | | |
| | No mutated | 67 | 21 | 1.00 | 1.00 | | Mutated | 2 | 0 | — | — |
| | mEH (139) | | | | |
| | His/His | 45 | 24 | 1.00 | 1.00 | | His/Arg | 20 | 10 | 1.28 (0.50–3.31) | 0.83 (0.30–2.30) | | Arg/arg | 4 | 0 | — | — |
| | GSTM1 | | | | |
| | Present | 35 | 16 | 1.00 | 1.00 | | Absent | 34 | 18 | 0.79 (0.34–1.86) | 0.69 (0.28–1.72) |
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