Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells
Figure 2
Effect of biochanin A on HER-2 and p-HER-2 protein expression. (a) SK-BR-3 breast cancer cells were seeded in a T-75 flask in RPMI-1640 cell culture media (10% FBS). Following 72 hours of treatment with biochanin A (2–50 M) HER-2 and p-HER-2 protein expression was evaluated. The data indicate reduced HER-2 phosphorylation with 50 M biochanin A (; ). C: control or no treatment; DMSO: vehicle (Statistical analysis: One-way Anova, , *). (b) Representative blot for HER-2 and p-HER-2 protein expression.
