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Journal of Oncology
Volume 2009 (2009), Article ID 247873, 4 pages
http://dx.doi.org/10.1155/2009/247873
Case Report

Antiangiogenic Therapy in the Treatment of Recurrent Medulloblastoma in the Adult: Case Report and Review of the Literature

U.O. Radiodiagnostica e Radioterapia Oncologica, AOU Policlinico “G. Rodolico”—Catania, Via Santa Sofia 78-95125—Catania, Italy

Received 27 May 2009; Revised 9 August 2009; Accepted 3 November 2009

Academic Editor: David Ball

Copyright © 2009 Giuseppe Privitera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Medulloblastoma is a rare tumor in central nervous system, with an even rarer occurrence in adulthood. The management of a recurrent disease is a medical challenge; chemotherapy has been used as the treatment of choice, while reirradiation has been employed in selected cases. We report the case of a 51-year-old man with recurrent medulloblastoma. He was treated with local reirradiation, chemotherapy, and antiangiogenic drug, with the latter giving the longer progression-free interval. The aim of this report is to show that recurrent medulloblastoma in adults can be approached with a multimodality treatment and that antiangiogenic therapy should have a role in the management of this disease.