Journal of Oncology / 2009 / Article / Tab 1

Review Article

MicroRNAs as New Players for Diagnosis, Prognosis, and Therapeutic Targets in Breast Cancer

Table 1

List of miRNAs and their target gene involved in human breast cancer.

MicroRNATargetsAberrant expression and rolesReferences

MiR-21BCL2, TPM1, PDCD4, PTENOverexpressed and play oncogenic role[1417]
MiR-10bHomeobox D10Down modulated, but associated with metastatic potential[20]
MiR-27aZBTB10Oncogenic role in breast cancer cells[21]
MiR-206ER Overexpressed[22, 23]
MiR-17-5pAIB1Oncosuppressor in breast cell lines[24]
MiR-125a, miR-125bERBB2, ERBB3Down modulated and act as oncosuppressor[9, 25]
Let-7RAS, HMGA2Down modulated and reduced in BT-ICs[26]
MiR-205HER3Down modulated[27]

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