MMP9 but Not EGFR, MET, ERCC1, P16, and P-53 Is Associated with Response to Concomitant Radiotherapy, Cetuximab, and Weekly Cisplatin in Patients with Locally Advanced Head and Neck Cancer
Table 3
Selected patient and tumor characteristics, EGFR, MET, p-53, HPV-16, and p16 status and response to CCRT.
n
Primary site
Gender
Age
Response
EGFR
EGFR
EGFR
MET
MET
MET
p-53
HPV-16
p16
(years)
(IHC)
(FISH)
(mRNA)
(IHC)
(FISH)
(FISH)
(IHC)
(DNA)
(IHC)
Oral cavity
W
69
PR
LLG
H
N
TR
GAIN
5
N
N
Oral cavity
M
66
PR
DI
H
P
TR
GAIN
90
N
N
Oral cavity
M
59
PR
TR
H
N
TR
GAIN
90
N
N
Oral cavity
M
82
CR
DI
H
N
LP
GAIN
90
P
N
Oral cavity
M
61
NE
TR
L
P
LP
GAIN
90
P
N
Oral cavity
M
69
PD
DI
L
N
DI
NORMAL
90
—
—
Oral cavity
W
41
PD
DI
L
P
TR
GAIN
80
—
N
Oral cavity
W
60
CR
TR
H
P
TR
GAIN
0
N
N
Oral cavity
M
44
CR
TR
H
P
TR
GAIN
30–40
P
P
Oral cavity
M
60
ED
DI
L
P
TR
GAIN
90
N
P
Oral cavity
W
59
PD
DI
H
P
LP
GAIN
20–30
N
N
Oral cavity
W
55
CR
—
—
Undet.
—
—
—
—
—
—
Oropharynx
M
57
CR
AMPL
H
P
LP
GAIN
90
N
N
Oropharynx
W
36
CR
DI
L
N
LP
GAIN
5
P
P
Oropharynx
M
59
CR
DI
L
N
LP
GAIN
0
N
N
Oropharynx
W
55
CR
DI
L
P
LP
GAIN
30–40
P
P
Oropharynx
M
69
PR
DI
Undet.
N
DI
NORMAL
—
—
P
Oropharynx
M
46
CR
NE
—
H
—
—
—
—
N
P
Oropharynx
M
73
PD
TR
H
N
TR
GAIN
0
N
N
Oropharynx
M
67
SD
TR
H
P
DI
NORMAL
70–80
N
N
Hypopharynx
M
46
ED
TR
H
N
HP
GAIN
90
N
—
Hypopharynx
W
64
PR
NE
—
L
—
—
—
N
—
Hypopharynx
M
56
ED
TR
L
P
DI
NORMAL
90
P
N
Hypopharynx
W
56
PR
DI
L
N
—
—
0
—
—
Larynx
M
55
CR
DI
H
N
DI
NORMAL
0
N
N
Larynx
M
68
PR
DI
L
N
TR
GAIN
90
N
N
Larynx
M
60
ED
—
—
Undet.
—
—
—
—
—
—
Larynx
M
42
PR
DI
L
N
DI
NORMAL
90
N
N
Larynx
M
76
CR
LLG
L
N
DI
NORMAL
30–40
N
N
Larynx
M
74
ED
NE
DI
L
N
—
—
0
N
—
Larynx
W
46
SD
DI
L
P
TR
GAIN
5–10
N
P
Larynx
M
74
ED
DI
L
P
TR
GAIN
90
N
P
Larynx
M
67
PD
LLG
H
N
TR
GAIN
90
N
N
Larynx
M
54
CR
DI
H
N
TR
GAIN
0
N
N
Larynx
M
54
PR
DI
Undet.
N
DI
NORMAL
—
—
N
Paranasal Sinuses
M
65
SD
LLG
H
P
TR
GAIN
90
N
N
Major Salivary Gland
M
74
PR
TR
L
N
LP
GAIN
90
N
N
n = sample order number, M = man, W = woman. CR = complete response, PR = partial response, SD = stable disease, PD = progressive disease, NE = nonevaluable, ED = early death. LLG = low level gain, DI = disomy, HP = high polysomy, LP=low polysomy, TR = trisomy, AMPL = amplification. P = positive, N = negative, H = high, L = low, Undet. = undetermined by real time PCR.