Analysis of Candidate Genes in Occurrence and Growth of Colorectal Adenomas
Table 2
Association analysis between single polymorphisms and colorectal adenomas: P-values.
Polymophism
P-values for comparison
SA versus PF
LA versus PF
SA versus
TGFBR2.1
0.81
0.46
0.25
TGFBR2.2
0.66
0.63
0.86
TGFBR2.3
0.91
0.94
0.92
MLH1.1
0.87
0.16
0.30
MLH1.2
0.69
0.75
0.68
MSH2.1
0.33
0.87
0.32
MSH2.2
0.57
0.93
0.57
MSH2.3
0.64
0.88
0.55
MSH2.4
0.71
0.85
0.80
MYH.1
0.82
0.71
0.56
P53.1
0.56
0.23
0.20
P53.2
0.40
0.16
0.78
P53.3
0.16
0.41
0.86
AXIN2.1
0.13
0.66
0.76
AXIN2.2
0.78
0.63
0.49
AXIN2.3
0.29
0.46
0.85
AXIN2.4
0.19
0.08
0.75
AXIN2.5
0.37
0.60
0.27
AXIN2.6
0.77
0.55
0.48
AXIN2.7
0.27
0.18
0.06
AXIN2.8
0.38
0.29
0.53
AXIN2.9
0.53
0.04
0.03
BAX.1
0.95
0.68
0.80
BAX.2
0.95
0.26
0.48
BAX.3
0.64
0.49
0.83
CTNNB1.1
0.58
0.64
0.85
CTNNB1.2
0.93
0.15
0.48
UGT1A1
0.05
0.29
0.76
APC.1
APC.2
0.80
0.26
0.38
CARD15.1
0.97
0.15
0.18
CARD15.2
0.48
0.57
0.97
MDR1.1
0.10
0.23
0.59
MDR1.2
0.69
0.04
0.09
TS.1
0.47
0.29
0.44
TS .2
0.41
0.25
0.87
HRAS1
0.38
0.17
0.65
-value for the Wald test assessing the global effect of SNP, uncorrected for multiple testing. LA large adenoma, SA small adenoma, PF polyp-free. Exact test.
