Table of Contents Author Guidelines Submit a Manuscript
Journal of Oncology
Volume 2009, Article ID 342391, 6 pages
Review Article

TGF- 1-Induced Expression of the Poor Prognosis SERPINE1/PAI-1 Gene Requires EGFR Signaling: A New Target for Anti-EGFR Therapy

Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA

Received 29 November 2008; Accepted 30 January 2009

Academic Editor: Daniel Chua

Copyright © 2009 Rohan Samarakoon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [20 citations]

The following is the list of published articles that have cited the current article.

  • Leida B. Rozeman, Inge H. Briaire de Bruijn, Patrizia Bacchini, Eric L. Staals, Franco Bertoni, Judith V. M. G. Bovee, and Pancras C. W. Hogendoorn, “Dedifferentiated peripheral chondrosarcomas: regulation of EXT-downstream m olecules and differentiation-related genes,” Modern Pathology, vol. 22, no. 11, pp. 1489–1498, 2009. View at Publisher · View at Google Scholar
  • Jennifer Freytag, Cynthia E. Wilkins-Port, Craig E. Higgins, J. Andrew Carlson, Agnes Noel, Jean-Michel Foidart, Stephen P. Higgins, Rohan Samarakoon, and Paul J. Higgins, “PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma,” Journal of Oncology, vol. 2009, pp. 1–12, 2009. View at Publisher · View at Google Scholar
  • Serkan Sertel, Tolga Eichhorn, Christian H. Simon, Peter K. Plinkert, Steven W. Johnson, and Thomas Efferth, “Pharmacogenomic Identification of c-Myc/Max-Regulated Genes Associated with Cytotoxicity of Artesunate towards Human Colon, Ovarian and Lung Cancer Cell Lines,” Molecules, vol. 15, no. 4, pp. 2886–2910, 2010. View at Publisher · View at Google Scholar
  • Petra Richter, Claudia Umbreit, Marcus Franz, Angela Berndt, Susanne Grimm, Andrea Uecker, Frank D. Boehmer, Hartwig Kosmehl, and Alexander Berndt, “EGF/TGF beta 1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332,” Journal of Oral Pathology & Medicine, vol. 40, no. 1, pp. 46–54, 2011. View at Publisher · View at Google Scholar
  • Cristina Oliveras-Ferraros, Alejandro Vazquez-Martin, Silvia Cufi, Bernardo Queralt, Luciana Baez, Raquel Guardeno, Xavier Hernandez-Yaguee, Begona Martin-Castillo, Joan Brunet, and Javier A. Menendez, “Stem Cell Property Epithelial-to-Mesenchymal Transition is a Core Transcriptional Network for Predicting Cetuximab (Erbitux (TM)) Efficacy in KRAS Wild-Type Tumor Cells,” Journal Of Cellular Biochemistry, vol. 112, no. 1, pp. 10–29, 2011. View at Publisher · View at Google Scholar
  • Gianluigi Mazzoccoli, Valerio Pazienza, Anna Panza, Maria Rosa Valvano, Giorgia Benegiamo, Manlio Vinciguerra, Angelo Andriulli, and Ada Piepoli, “ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer,” Journal Of Cancer Research And Clinical Oncology, vol. 138, no. 3, pp. 501–511, 2012. View at Publisher · View at Google Scholar
  • J. D. Tugwood, J. Kelsall, L. C. Coverley, F. R. Westwood, K. Haque, and R. D. J. Huby, “Fibrodysplasia Induced in Dog Skin by a Matrix Metalloproteinase (MMP) Inhibitor--A Mechanistic Analysis,” Toxicological Sciences, vol. 127, no. 1, pp. 236–245, 2012. View at Publisher · View at Google Scholar
  • Fang Liu, and Murray Korc, “Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells,” Molecular Cancer Therapeutics, vol. 11, no. 10, pp. 2138–2148, 2012. View at Publisher · View at Google Scholar
  • Yi-Ping Shih, Yoshikazu Takada, and Su Hao Lo, “Silencing of DLC1 Upregulates PAI-1 Expression and Reduces Migration in Nor mal Prostate Cells,” Molecular Cancer Research, vol. 10, no. 1, pp. 34–39, 2012. View at Publisher · View at Google Scholar
  • Jolieke G. van Oosterwijk, Danielle Meijer, Maayke A.J.H. van Ruler, Brendy E.W.M. van den Akker, Jan Oosting, Tibor Krenács, Piero Picci, Adrienne M. Flanagan, Bernadette Liegl-Atzwanger, Andreas Leithner, Nick Athanasou, Søren Daugaard, Pancras C.W. Hogendoorn, and Judith V.M.G. Bovée, “Screening for Potential Targets for Therapy in Mesenchymal, Clear Cell, and Dedifferentiated Chondrosarcoma Reveals Bcl-2 Family Members and TGFβ as Potential Targets,” The American Journal of Pathology, vol. 182, no. 4, pp. 1347–1356, 2013. View at Publisher · View at Google Scholar
  • W. Qiu, X. Wang, M. Buchanan, K. He, R. Sharma, L. Zhang, Q. Wang, and J. Yu, “ADAR1 is essential for intestinal homeostasis and stem cell maintenance,” Cell Death and Disease, vol. 4, no. 4, 2013. View at Publisher · View at Google Scholar
  • D S Zagoura, O Trohatou, V Bitsika, M Makridakis, K I Pappa, A Vlahou, M G Roubelakis, and N P Anagnou, “AF-MSCs fate can be regulated by culture conditions,” Cell Death and Disease, vol. 4, no. 4, pp. e571, 2013. View at Publisher · View at Google Scholar
  • Ju Eun Lim, Moo Suk Park, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Se Kyu Kim, Hyo Sup Shim, Byoung Chul Cho, and Joon Chang, “ Plasminogen Activator Inhibitor Type 1 ( PAI-1 ) A15T Gene Polymorphism Is Associated with Prognosis in Patients with EGFR Mutation Positive Pulmonary Adenocarcinoma ,” Tuberculosis and Respiratory Diseases, vol. 75, no. 4, pp. 140, 2013. View at Publisher · View at Google Scholar
  • Jelena Krstic, Irina Maslovaric, and Juan F. Santibanez, “Novel patents and cancer therapies for transforming growth factor-beta and urokinase type plasminogen activator: Potential use of their interplay in tumorigenesis,” Recent Patents on Anti-Cancer Drug Discovery, vol. 9, no. 3, pp. 354–371, 2014. View at Publisher · View at Google Scholar
  • Tina Horbach, Claudia Götz, Thomas Kietzmann, and Elitsa Y. Dimova, “Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer,” Frontiers in Pharmacology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Xiaofan Mi, Haijing Sun, Nan Gao, Chenxi Yan, and Fu-Shin Yu, “Hyperglycemia-suppressed expression of serpine1 contributes to delayed epithelial wound healing in diabetic mouse corneas,” Investigative Ophthalmology and Visual Science, vol. 56, no. 5, pp. 3383–3392, 2015. View at Publisher · View at Google Scholar
  • Jian Liu, David A. Copland, Sofia Theodoropoulou, Hsi An Amy Chiu, Miriam Durazo Barba, Ka Wang Mak, Matthias Mack, Lindsay B. Nicholson, and Andrew D. Dick, “Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis,” Scientific Reports, vol. 6, pp. 20639, 2016. View at Publisher · View at Google Scholar
  • Daria Belik, Hilda Tsang, John Wharton, Luke Howard, Carmelo Bernabeu, and Beata Wojciak-Stothard, “Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis,” Journal of Biomedical Science, vol. 23, no. 1, 2016. View at Publisher · View at Google Scholar
  • Irene Arroyo-Solera, Maria Virtudes Céspedes, Xavier León, Ramón Mangues, Miguel Angel Pavón, and Isolda Casanova, “uPA/uPAR and SERPINE1 in head and neck cancer: Role in tumor resistance, metastasis, prognosis and therapy,” Oncotarget, vol. 7, no. 35, pp. 57351–57366, 2016. View at Publisher · View at Google Scholar
  • Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Chih-Wei Yen, Huang-Wei Xu, Yi-Fang Deng, Ying-Jhen Lin, Wan-Ting Hsu, Cheng-Shyong Wu, and Chin Li, “Upregulation of bone morphogenetic protein 1 is associated with poor prognosis of late-stage gastric Cancer patients,” BMC Cancer, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar