Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell Carcinomas

Table 3

Nuclear receptor target genes playing pivotal roles in diverse biological processes and cellular homeostasis were described to be differentially expressed in head and neck cancer.

NR	Target gene	Function	Reference - target gene	Reference - head and neck
PPAR	G0S2	Cell cycle	Zandbergen et al. Biochem J 2005	Tokumaru et al. Cancer Res 2004
	PDK1	Energy homeostasis	Degenhardt et al. J Mol Biol 2007	Wigfield et al. Br J Cancer 2008
RAR	p21WAF1/CIP1	Cell cycle	Liu et al. J Biol Chem 1996	Kapranos et al. Anticancer Res 2001
	BIRC5/surviving	Apoptosis	Pratt et al. J Cell Biochem 2003	Engels et al. J Pathol 2007
	C/EBPε	Transcription factor	Schwarz et al. Mol Cell Biol 1997	Bennett et al. Cancer Res 2007
	CRABP	Carrier protein	Nezzar et al. Mol Vis 2007	Won et al. Metabolism 2004
	cyclins, CDK	Cell cycle	Bour et al. Trends Cell Biol 2007	Jeannon et al. Clin Otolaryngol Allied Sci 1998
ER	c-Myc	Transcription factor	Markaverich et al. Steroids 2006	Pries et al. Int J Mol Med 2008
	Cyclins	Cell cycle	Eeckhoute et al. Genes Dev 2006	Nakashima et al. Eur Arch Otorhinolaryngol 2005 Lotayef et al. Br J Cancer 2000
	CRABP	Carrier protein	Li et al. J Biol Chem 2003	Vo et al. Anticancer Res 1998
	CXCl12/SDF-1	Chemokine/ligand	Hall et al. Mol Endocrinol 2003	Rehman et al. J Biol Chem 2008
	cathepsin D	Protease	Bretschneider et al. Mol Oncol 2008	Strojan et al. Anticancer Res 2000