Research Article
A Population-Based Clinical Trial of Irinotecan and Carboplatin
Table 5
Comparison of features of population based
versus modified-Fibonacci method in phase I trials.
| | Features | Population based | Fibonacci |
| | Number
of patients required | ~50 | ~20 | | Enrollment
of patients | Continuous | Cohorts of three | | Waiting time between cohorts | None | Required | | Efficacy
optimized | Yes | No | | Preliminary
efficacy data | Yes | Yes/No |
|
|
