Journal of Oncology / 2009 / Article / Tab 5

Research Article

A Population-Based Clinical Trial of Irinotecan and Carboplatin

Table 5

Comparison of features of population based versus modified-Fibonacci method in phase I trials.

FeaturesPopulation basedFibonacci

Number of patients required~50~20
Enrollment of patientsContinuousCohorts of three
Waiting time between cohortsNoneRequired
Efficacy optimized YesNo
Preliminary efficacy dataYesYes/No

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