Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals
Figure 3
In combination, genistein and DIM are more efficacious in the
downregulation of CXCR4 and CXCL12 mRNAs than either compound alone. The effect of downregulation of CXCR4 in (a) MDA-MB-231 and (b) BG-1 cells by 20 M DIM and 100 M genistein in combination is
greater than their individual effects. The same is seen in (b) BG-1 cells after CXCL12 quantification. Ctl = DMSO alone; , .
