Journal of Oncology / 2009 / Article / Fig 3

Research Article

Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals

Figure 3

In combination, genistein and DIM are more efficacious in the downregulation of CXCR4 and CXCL12 mRNAs than either compound alone. The effect of downregulation of CXCR4 in (a) MDA-MB-231 and (b) BG-1 cells by 20  M DIM and 100  M genistein in combination is greater than their individual effects. The same is seen in (b) BG-1 cells after CXCL12 quantification. Ctl = DMSO alone; , .
(a) MDA-MB-231
(b) BG-1

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