Journal of Oncology / 2009 / Article / Fig 4

Research Article

Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals

Figure 4

DIM specifically inhibits chemotaxis and chemoinvasion of breast and ovarian cancer cells toward CXCL12. (a) Quantification of chemotaxis of MCF-7 cells toward CXCL12 or FBS after treatment with DMSO alone (Ctl), 20  M DIM, 70  M genistein, or the combination of DIM + genistein for 24 hours. (b)-(c) Chemotaxis and chemoinvasion of MDA-MB-231 cells toward CXCL12 or IL-6 were quantified after pretreatment with DIM and/or genistein as in (a). (d) Quantification of chemoinvasion toward CXCL12 or FBS after treatment of BG-1 cells with DIM and/or genistein. , , ; compared with control + chemoattractant.
491985.fig.004a
(a) Chemotaxis of MCF-7 cells
491985.fig.004b
(b) Chemotaxis of MDA-MB-231 cells
491985.fig.004c
(c) Chemoinvasion of MDA-MB-231 cells
491985.fig.004d
(d) Chemoinvasion of BG-1 cells

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