Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals
Figure 4
DIM
specifically inhibits chemotaxis and chemoinvasion of breast and ovarian cancer
cells toward CXCL12. (a) Quantification of chemotaxis of MCF-7
cells toward CXCL12 or FBS after treatment with DMSO alone (Ctl), 20 M DIM,
70 M genistein, or the combination of DIM + genistein for 24 hours. (b)-(c) Chemotaxis and chemoinvasion of
MDA-MB-231 cells toward CXCL12 or IL-6 were quantified after pretreatment with
DIM and/or genistein as in (a). (d) Quantification of chemoinvasion
toward CXCL12 or FBS after treatment of BG-1 cells with DIM and/or
genistein. , , ; compared with control + chemoattractant.
