Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells
Figure 5
Association of perifosine-(PER-) induced cytotoxicity with glutathione (GSH) content and thioredoxin reductase activity (TrxRed) in head and neck cancer cells. FaDu, Cal-27, and SCC-25 cells were analyzed for mean baseline TrxRed activity (a) and mean total GSH content (b) and compared to their respective mean surviving fraction in response to 5 M PER (FaDu and Cal-27) or 10 M PER (SCC-25).
