Autoantibodies to Tumor-Associated Antigens in Epithelial Ovarian Carcinoma

Table 1

Frequency of identified circulating AAbs to TAAs in epithelial ovarian carcinoma.

AAb to TAA	Positive	Total	%	Comment	Reference
p53	10	30	33		[43]
p53	42	174	24	Association with shorter disease-free survival.	[30]
p53	18	86	21	No prognostic relevance for survival.	[22]
p53	143	652	22	Summary of 11 studies. Frequency of AAbs: 8.7%–92.3%. Few studies showed association with poor histological differentiation and poor survival.	[23]
p53	38	83	46	Association with higher risk for relapse.	[38]
p53	21	113	19	Correlation with tumor stage and grade. Association with worse survival.	[28]
p53	28	113	25	Serum AAbs had no prognostic relevance for survival. Ascitic AAbs were associated with adverse survival.	[24]
p53	24	193	13	No diagnostic value, even if combined with CA-125. No prognostic relevance for survival.	[45]
p53	29	116	25	Detected exclusively in type II carcinoma.	[33]
HOXA7	17	48	36	Allows no distinction between benign and malignant ovarian tumors.	[15]
HOXB7	13	39	33	Significant difference in the frequency of AAbs between ovarian carcinoma patients and healthy controls. Promising diagnostic potential.	[48]
HSP-27	17	34	50	Promising diagnostic potential. Possible association with improved survival.	[49]
HSP-90	8	32	25	Association with advanced-stage disease. Promising diagnostic potential.	[9]
Cathepsin D	10	25	40	Promising diagnostic potential.	[50]
NY-ESO-1/LAGE-1	NR	NR	13		[51]
NY-ESO-1/LAGE-1	11	37	30	No prognostic relevance for survival. Promising diagnostic potential.	[11]
MUC1	306	668	46	Correlation with a more favorable prognosis.	[52]
GIPC-1	6	11	54	Promising diagnostic potential.	[53]
IL-8	NR	94	NR	Anti-IL-8 AAb levels were elevated in ovarian carcinoma patients as compared with those of healthy controls. Promising diagnostic potential.	[54]
Ep-CAM	22	52	42	Potential diagnostic value.	[55]
S100A7	NR	92	NR	Mean AAbs level was significantly higher in ovarian carcinoma patients as compared to that healthy controls. Potential diagnostic value.	[2]

NR, not recorded.