In Vivo Measurements of Tumor Metabolism and Growth after Administration of Enzastaurin Using Small Animal FDG Positron Emission Tomography
Figure 1
Correlation of Standard Caliper Measurements to FDG-PET uptake measured by SUV (Panel (a) and Correlation of SUV with CT-based Tumor Size (Panel (b): U87MG xenograft tumor cell growth was assessed over a period of 3 weeks using standard caliper measurements (mm3), serial FDG-PET uptake, and tumor size by CT scan (see Material and Methods). Correlation between the three different tumor growth measurements was plotted after 2 weeks (open symbols) and after 3 weeks (closed symbols) of tumor growth. Correlation between standard caliper measurements and standardized uptake value (SUV) was plotted (Panel (a), and SUV was correlated with tumor size determined by CT scan (Panel (b) (correlation coefficient 0.8, ). (Correlation excludes one mouse with necrotic intratumoral tissue at Week 3 indicated by ■.)
