Prognostic Factors in Patients with Multiple Recurrences of Well-Differentiated Thyroid Carcinoma

Table 2

Patient, tumour, treatment, and recurrence data for patients with multiple recurrences of well-differentiated thyroid carcinoma.

Age >45	^∗∗𝑃=.0093
Gender (M Versus F)	𝑃=.7876
Extent of initial surgery (ST versus TT)	𝑃=.0964
Neck dissection	𝑃=.1978
Iodine 131 therapy	𝑃=.1749
External beam radiation therapy	^∗𝑃=.0167
Histologic type—overall	𝑃=.1362
Tall cell versus others	^†𝑃=.0748
Stage I/II versus IV	^∗∗𝑃=.0052
Size >4cm	^†𝑃=.0621
Multifocal disease	^†𝑃=.0795
Lymphatic invasion	𝑃=.9361
Vascular invasion	^∗∗∗𝑃=.0002
Extrathyriodal extention	^†𝑃=.0772
Distant metastasis	^∗∗∗𝑃=.0002
MACIS >6	^∗∗𝑃=.0061
Time to recurrence <12 months	^∗𝑃=.0270
Site of recurrence	^†𝑃=.0560
Mode of detection
Clinical	𝑃=.6328
Imaging	𝑃=.5752
Thyroglobulin	𝑃=.7497
Treatment of recurrence
Surgery	𝑃=.4128
Iodine 131 therapy	𝑃=.6281
External beam radiation therapy	𝑃=.8889

ST: subtotal thyroidectomy;    TT: total thyroidectomy
^∗𝑃<.05;   ^∗∗𝑃<.01;   ^∗∗∗𝑃<.001
† trend toward significance.