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Journal of Oncology
Volume 2009, Article ID 672492, 8 pages
Research Article

Circulating Vitamin D and Risk of Epithelial Ovarian Cancer

1Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
2Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
3New York University Cancer Institute, New York, NY 10016, USA
4Department of Medical Biosciences, University of Umeå, 901 87 Umeå, Sweden
5Department of Public Health and Clinical Medicine/Nutritional Research, University of Umeå, 901 87 Umeå, Sweden
6Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
7Radiation Effects Research Foundation, Hiroshima 732-0815, Japan

Received 21 April 2009; Accepted 24 June 2009

Academic Editor: Boffetta Paolo

Copyright © 2009 Alan A. Arslan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We conducted a nested case-control study within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Health and Disease Study, to examine the association between prediagnostic circulating levels of 25-hydroxy vitamin D (25(OH)D) and the risk of subsequent invasive epithelial ovarian cancer (EOC). The 25(OH)D levels were measured in serum or plasma from 170 incident cases of EOC and 373 matched controls. Overall, circulating 25(OH)D levels were not associated with the risk of EOC in combined cohort analysis: adjusted OR for the top tertile versus the reference tertile, 1.09 (95% CI, 0.59–2.01). In addition, there was no evidence of an interaction effect between VDR SNP genotype or haplotype and circulating 25(OH)D levels in relation to ovarian cancer risk, although more complex gene-environment interactions may exist.