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Journal of Oncology
Volume 2009, Article ID 672492, 8 pages
http://dx.doi.org/10.1155/2009/672492
Research Article

Circulating Vitamin D and Risk of Epithelial Ovarian Cancer

1Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
2Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
3New York University Cancer Institute, New York, NY 10016, USA
4Department of Medical Biosciences, University of Umeå, 901 87 Umeå, Sweden
5Department of Public Health and Clinical Medicine/Nutritional Research, University of Umeå, 901 87 Umeå, Sweden
6Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
7Radiation Effects Research Foundation, Hiroshima 732-0815, Japan

Received 21 April 2009; Accepted 24 June 2009

Academic Editor: Boffetta Paolo

Copyright © 2009 Alan A. Arslan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Dokoh, C. A. Donaldson, S. L. Marion, J. W. Pike, and M. R. Haussler, “The ovary: a target organ for 1,25-dihydroxyvitamin D3,” Endocrinology, vol. 112, no. 1, pp. 200–206, 1983. View at Google Scholar
  2. D. E. Saunders, C. Christensen, J. R. Williams et al., “Inhibition of breast and ovarian carcinoma cell growth by 1,25-dihydroxyvitamin D3 combined with retinoic acid or dexamethasone,” Anti-Cancer Drugs, vol. 6, no. 4, pp. 562–569, 1995. View at Google Scholar
  3. F. Jiang, P. Li, A. J. Fornace Jr., S. V. Nicosia, and W. Bai, “G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer,” Journal of Biological Chemistry, vol. 278, no. 48, pp. 48030–48040, 2003. View at Publisher · View at Google Scholar
  4. F. Jiang, J. Bao, P. Li, S. V. Nicosia, and W. Bai, “Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase,” Journal of Biological Chemistry, vol. 279, no. 51, pp. 53213–53221, 2004. View at Publisher · View at Google Scholar
  5. P. Li, C. Li, X. Zhao, X. Zhang, S. V. Nicosia, and W. Bai, “p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase,” Journal of Biological Chemistry, vol. 279, no. 24, pp. 25260–25267, 2004. View at Google Scholar
  6. X. Zhang, F. Jiang, P. Li et al., “Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089,” Clinical Cancer Research, vol. 11, no. 1, pp. 323–328, 2005. View at Google Scholar
  7. E. S. Lefkowitz and C. F. Garland, “Sunlight, vitamin D, and ovarian cancer mortality rates in US women,” International Journal of Epidemiology, vol. 23, no. 6, pp. 1133–1136, 1994. View at Google Scholar
  8. W. B. Grant, “An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation,” Cancer, vol. 94, no. 6, pp. 1867–1875, 2002. View at Publisher · View at Google Scholar
  9. D. M. Freedman, M. Dosemeci, and K. McGlynn, “Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control study,” Occupational and Environmental Medicine, vol. 59, no. 4, pp. 257–262, 2002. View at Publisher · View at Google Scholar
  10. C. F. Garland, S. B. Mohr, E. D. Gorham, W. B. Grant, and F. C. Garland, “Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer,” American Journal of Preventive Medicine, vol. 31, no. 6, pp. 512–514, 2006. View at Publisher · View at Google Scholar
  11. E. Salazar-Martinez, E. C. Lazcano-Ponce, G. G. Lira-Lira, P. Escudero-De Los Rios, and M. Hernandez-Avila, “Nutritional determinants of epithelial ovarian cancer risk: a case-control study in Mexico,” Oncology, vol. 63, no. 2, pp. 151–157, 2002. View at Publisher · View at Google Scholar
  12. L. H. Kushi, P. J. Mink, A. R. Folsom et al., “Prospective study of diet and ovarian cancer,” American Journal of Epidemiology, vol. 149, no. 1, pp. 21–31, 1999. View at Google Scholar
  13. E. Bidoli, C. L. Vecchia, R. Talamini et al., “Micronutrients and ovarian cancer: a case-control study in Italy,” Annals of Oncology, vol. 12, no. 11, pp. 1589–1593, 2001. View at Publisher · View at Google Scholar
  14. M. T. Goodman, A. H. Wu, K.-H. Tung et al., “Association of dairy products, lactose, and calcium with the risk of ovarian cancer,” American Journal of Epidemiology, vol. 156, no. 2, pp. 148–157, 2002. View at Publisher · View at Google Scholar
  15. D. O. Koralek, E. R. Bertone-Johnson, M. F. Leitzmann et al., “Relationship between calcium, lactose, vitamin D, and dairy products and ovarian cancer,” Nutrition and Cancer, vol. 56, no. 1, pp. 22–30, 2006. View at Publisher · View at Google Scholar
  16. J. M. Genkinger, D. J. Hunter, D. Spiegelman et al., “Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies,” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 2, pp. 364–372, 2006. View at Publisher · View at Google Scholar
  17. M. R. Sowers, R. B. Wallace, B. W. Hollis, and J. H. Lemke, “Parameters related to 25-OH-D levels in a population-based study of women,” The American Journal of Clinical Nutrition, vol. 43, no. 4, pp. 621–628, 1986. View at Google Scholar
  18. R. P. Heaney, K. M. Davies, T. C. Chen, M. F. Holick, and M. J. Janet Barger-Lux, “Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol,” The American Journal of Clinical Nutrition, vol. 77, no. 1, pp. 204–210, 2003. View at Google Scholar
  19. A. Burgaz, A. Åkesson, A. Öster, K. Michaëlsson, and A. Wolk, “Associations of diet, supplement use, and ultraviolet B radiation exposure with vitamin D status in Swedish women during winter,” The American Journal of Clinical Nutrition, vol. 86, no. 5, pp. 1399–1404, 2007. View at Google Scholar
  20. H. Sahota, H. Barnett, M. Lesosky, J. M. Raboud, R. Vieth, and J. A. Knight, “Association of vitamin D-related information from a telephone interview with 25-hydroxyvitamin D,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 1, pp. 232–238, 2008. View at Publisher · View at Google Scholar
  21. M. F. Holick, “Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease,” The American Journal of Clinical Nutrition, vol. 80, no. 6, supplement, pp. 1678S–1688S, 2004. View at Google Scholar
  22. J. E. Zerwekh, “Blood biomarkers of vitamin D status,” The American Journal of Clinical Nutrition, vol. 87, no. 4, pp. 1087S–1091S, 2008. View at Google Scholar
  23. M. F. Holick, “Vitamin D status: measurement, interpretation, and clinical application,” Annals of Epidemiology, vol. 19, no. 2, pp. 73–78, 2009. View at Publisher · View at Google Scholar
  24. D. Wolpowitz and B. A. Gilchrest, “The vitamin D questions: how much do you need and how should you get it?” Journal of the American Academy of Dermatology, vol. 54, no. 2, pp. 301–317, 2006. View at Publisher · View at Google Scholar
  25. S. S. Tworoger, I.-M. Lee, J. E. Buring, B. Rosner, B. W. Hollis, and S. E. Hankinson, “Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 4, pp. 783–788, 2007. View at Publisher · View at Google Scholar
  26. T. V. Clendenen, A. A. Arslan, K. L. Koenig et al., “Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer,” Cancer Letters, vol. 260, no. 1-2, pp. 209–215, 2008. View at Publisher · View at Google Scholar
  27. G. Lurie, L. R. Wilkens, P. J. Thompson et al., “Vitamin D receptor gene polymorphisms and epithelial ovarian cancer risk,” Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 12, pp. 2566–2571, 2007. View at Publisher · View at Google Scholar
  28. S. S. Tworoger, M. A. Gate, I.-M. Lee et al., “Polymorphisms in the vitamin D receptor and risk of ovarian cancer in four studies,” Cancer Research, vol. 69, no. 5, pp. 1885–1891, 2009. View at Publisher · View at Google Scholar
  29. G. Hallmans, A. Agren, G. Johansson et al., “Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort—evaluation of risk factors and their interactions,” Scandinavian Journal of Public Health, vol. 31, supplement 61, pp. 18–24, 2003. View at Google Scholar
  30. P. G. Toniolo, B. S. Pasternack, R. E. Shore et al., “Endogenous hormones and breast cancer: a prospective cohort study,” Breast Cancer Research and Treatment, vol. 18, supplement 1, pp. S23–S26, 1991. View at Google Scholar
  31. P. G. Toniolo, M. Levitz, A. Zeleniuch-Jacquotte et al., “A prospective study of endogenous estrogens and breast cancer in postmenopausal women,” Journal of the National Cancer Institute, vol. 87, no. 3, pp. 190–197, 1995. View at Google Scholar
  32. C. B. Borkowf, P. S. Albert, and C. C. Abnet, “Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories,” Statistics in Medicine, vol. 22, no. 9, pp. 1477–1493, 2003. View at Publisher · View at Google Scholar
  33. S. Arunabh, S. Pollack, J. Yeh, and J. F. Aloia, “Body fat content and 25-hydroxyvitamin D levels in healthy women,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 1, pp. 157–161, 2003. View at Publisher · View at Google Scholar
  34. J. M. Gomez , F. J. Maravall, N. Gomez, M. A. Navarro, R. Casamitjana, and J. Soler, “Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population,” Hormone and Metabolic Research, vol. 36, no. 1, pp. 48–53, 2004. View at Google Scholar
  35. J. A. Lucas, M. J. Bolland, A. B. Grey et al., “Determinants of vitamin D status in older women living in a subtropical climate,” Osteoporosis International, vol. 16, no. 12, pp. 1641–1648, 2005. View at Publisher · View at Google Scholar
  36. M. B. Snijder, R. M. van Dam, M. Visser et al., “Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 7, pp. 4119–4123, 2005. View at Publisher · View at Google Scholar
  37. D. M. Freedman, S.-C. Chang, R. T. Falk et al., “Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 4, pp. 889–894, 2008. View at Publisher · View at Google Scholar
  38. D. A. Brouwer, J. van Beek, H. Ferwerda et al., “Rat adipose tissue rapidly accumulates and slowly releases an orally-administered high vitamin D dose,” British Journal of Nutrition, vol. 79, no. 6, pp. 527–532, 1998. View at Publisher · View at Google Scholar
  39. M. Blum, G. Dolnikowski, E. Seyoum et al., “Vitamin D(3) in fat tissue,” Endocrine, vol. 33, no. 1, pp. 90–94, 2008. View at Google Scholar
  40. A. Kilkkinen, P. Knekt, M. Heliövaara et al., “Vitamin D status and the risk of lung cancer: a cohort study in Finland,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 11, pp. 3274–3278, 2008. View at Publisher · View at Google Scholar
  41. D. Feskanich, J. Ma, C. S. Fuchs et al., “Plasma vitamin D metabolites and risk of colorectal cancer in women,” Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 9, pp. 1502–1508, 2004. View at Google Scholar
  42. S. S. Harris and B. Dawson-Hughes, “The association of oral contraceptive use with plasma 25-hydroxyvitamin D levels,” Journal of the American College of Nutrition, vol. 17, no. 3, pp. 282–284, 1998. View at Google Scholar
  43. S. Nesby-O'Dell, K. S. Scanlon, M. E. Cogswell et al., “Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third national health and nutrition examination survey, 1988–1994,” The American Journal of Clinical Nutrition, vol. 76, no. 1, pp. 187–192, 2002. View at Google Scholar
  44. J. Ma, M. J. Stampfer, P. H. Gann et al., “Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians,” Cancer Epidemiology Biomarkers and Prevention, vol. 7, no. 5, pp. 385–390, 1998. View at Google Scholar
  45. M. Laaksonen, M. Kärkkäinen, T. Outila, T. Vanninen, C. Ray, and C. Lamberg-Allardt, “Vitamin D receptor gene BsmI-polymorphism in Finnish premenopausal and postmenopausal women: its association with bone mineral density, markers of bone turnover, and intestinal calcium absorption, with adjustment for lifestyle factors,” Journal of Bone and Mineral Metabolism, vol. 20, no. 6, pp. 383–390, 2002. View at Publisher · View at Google Scholar
  46. H. M. Macdonald, F. E. McGuigan, A. Stewart et al., “Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women,” Journal of Bone and Mineral Research, vol. 21, no. 1, pp. 151–162, 2006. View at Publisher · View at Google Scholar
  47. N. E. Lane, L. R. Gore, S. R. Cummings et al., “Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Study of Osteoporotic Fractures Research Group,” Arthritis and Rheumatism, vol. 42, no. 5, pp. 854–860, 1999. View at Google Scholar
  48. E. A. Platz, M. F. Leitzmann, B. W. Hollis, W. C. Willett, and E. Giovannucci, “Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancer,” Cancer Causes and Control, vol. 15, no. 3, pp. 255–265, 2004. View at Publisher · View at Google Scholar
  49. P. Lips, “Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications,” Endocrine Reviews, vol. 22, no. 4, pp. 477–501, 2001. View at Publisher · View at Google Scholar
  50. C. F. Garland, F. C. Garland, E. D. Gorham et al., “The role of vitamin D in cancer prevention,” American Journal of Public Health, vol. 96, no. 2, pp. 252–261, 2006. View at Publisher · View at Google Scholar
  51. J. I. Pedersen, “Vitamin D requirement and setting recommendation levels—current Nordic view,” Nutrition Reviews, vol. 66, supplement 2, pp. S165–S169, 2008. View at Publisher · View at Google Scholar
  52. H. A. Bischoff-Ferrari, E. Giovannucci, W. C. Willett, T. Dietrich, and B. Dawson-Hughes, “Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes,” The American Journal of Clinical Nutrition, vol. 84, no. 1, pp. 18–28, 2006. View at Google Scholar