Circulating Vitamin D and Risk of Epithelial Ovarian Cancer

Table 1

Characteristics of invasive epithelial ovarian cancer cases and matched controls, NYUWHS and NSHDS cohorts.

Characteristic	NYUWHS		NSHDS
	Cases (𝑛=71)	Controls (𝑛=125)	Cases (𝑛=97)	Controls (𝑛=191)
Age at sampling, median (25%–75%), y	55 (47–62)	55 (46–62)	52 (50–60)	51 (50–60)
Time to diagnosis, ^∗median (25%–75%), y	7.0 (3.7–9.5)	—	4.6 (2.0–7.1)	—
BMI at sampling, median (25%–75%), kg/m^2	25 (22–28)	25 (23–28)	25 (23–28)	25 (23–28)
Menopausal status at enrollment,^†𝑛 (%)
Premenopausal	29 (40.8)	52 (41.6)	30 (30.9)	53 (27.7)
Postmenopausal	42 (59.2)	73 (58.4)	67 (69.1)	138 (72.3)
Parity, ^†,‡𝑛 (%)
Never	28 (39.4)	39 (31.2)	18 (22.5)	19 (11.0)
Ever	43 (60.6)	86 (68.8)	62 (77.5)	153 (89.0)
OC use, ^†,‡𝑛 (%)
Never	39 (70.9)	63 (68.5)	54 (67.5)	89 (54.6)
Ever	16 (29.1)	29 (31.5)	26 (32.5)	74 (45.4)
Unknown
Smoking status, ^†𝑛 (%)
Never	25 (40.3)	38 (38.8)	53 (61.6)	100 (56.8)
Ever	37 (59.7)	60 (61.2)	33 (38.4)	76 (43.2)
25(OH)D, median (25%–75%), nmol/L	47.8 (31.4–64.5)	45.8 (28.1–59.8)	37.6 (29.5–46.5)	39.4 (32.8–47.8)

^∗Differs significantly between NYUWHS and NSHDS cases at 𝑃=.0001. ^†NYUWHS and NSHDS controls differ significantly (𝑃<.05) with regard to age at menarche, menopausal status, parity, ever use of oral contraceptives, smoking status, and 25(OH)D. ^‡Case-control differences significant only for NSHDS for parity (𝑃=.01) and for oral contraceptives use (𝑃=.03).