Circulating Vitamin D and Risk of Epithelial Ovarian Cancer

Table 4

Odds ratios for invasive epithelial ovarian cancer by tertile of 25(OH)D.

	ORs for season-adjusted 25(OH)D tertiles			P-trend
	Tertile 1	Tertile 2	Tertile 3
NYUWHS	≤36.7 nmol/L	36.8–57.7 nmol/L	≥ 57.8 nmol/L
𝑛, case/control	22/42	23/43	26/38
Model 1^∗	1.0 (reference)	0.97 (0.45–2.06)	1.35 (0.59–3.09)	0.50
Model 2^†	1.0 (reference)	1.13 (0.39–3.27)	1.50 (0.53–4.23)	0.44
NSHDS	≤34.0 nmol/L	34.1–44.7 nmol/L	≥ 44.8 nmol/L
𝑛, case/control	37/58	28/70	32/63
Model 1^∗	1.0 (reference)	0.62 (0.33–1.11)	0.79 (0.42–1.46)	0.49
Model 2^†	1.0 (reference)	0.54 (0.25–1.17)	0.83 (0.38–1.81)	0.78
Combined cohorts	Cohort-specific cut points	Cohort-specific cut points	Cohort-specific cut points
𝑛, case/control	59/100	51/113	58/101
Model 1^∗	1.0 (reference)	0.74 (0.46–1.20)	0.96 (0.59–1.58)	0.88
Model 2^†	1.0 (reference)	0.78 (0.42–1.43)	1.09 (0.59–2.01)	0.71

^∗Conditional logistic regression model controlling for matching factors only: cohort, age at entry, and date of blood donation. ^† Conditional logistic regression model controlling for matching factors and additionally adjusted for oral contraceptive use (ever/never) and parity (ever/never) after exclusion of the participants with missing data for these variables (NYUWHS: 𝑛=49, NSHDS: 𝑛=49).