Journal of Oncology / 2009 / Article / Tab 1

Research Article

Response of Patient-Derived Non-Small Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance Markers

Table 1

Chemosensitivity testing, constitutive protein, and mRNA expression of BCRP, LRP, MDR1, and MRP1 in 26 xenografts and the positive controls. Response: − negativ: 100–50% T/C, + 35–50% T/C, ++ 21–35% T/C, +++ 6–20%T/C, ++++ 0–5% T/C, tox-toxic, n.t.—not tested; protein expression: − not detected, + weak, ++ medium, +++ strong expression; % of positive cells; mRNA expression: normalised values; etp—etoposide, carpl—carboplatin, gem—gemcitabine, paltx—paclitaxel, erlo—erlotinib.

Before treatment
ChemosensitivityProtein expressionmRNA expression
LuCaetpCarplgempaltxerloBCRPLRPMDR1 [%]MRP1 [%]bcrplrpmdr1mrp1

7064+++++++15.413.812.198.0117.547.10
7126+++++++++15.318.24.175.0418.183.45
7166++++++++13.713.815.466.4507.16
7177+++++++++14.529.510.425.3316.972.02
7187+++++++15.418.38.136.9007.55
7198++++++++27.220.910.136.1821.246.25
7298++++++++14.413.115.035.7917.196.33
7336(+) ++ +++++++13.313.68.086.6807.02
7343++++++++++20.824.18.345.8505.23
7387+++++++++++15.429.96.157.6410.907.57
7406++++++++++++29.422.414.877.6114.978.10
7414+++++++++++17.915.67.135.6906.21
7433++++++++++18.822.16.995.6817.203.73
7462+++++++++++39.831.37.655.249.367.78
7466+++++++++++++15.518.68.627.5622.438.65
7506++++(+)+++++65.819.010.967.0715.946.98
7530++++tox+++++++20.116.114.278.2414.358.01
7558+++++++ +++++24.025.315.906.2618.646.38
7612++++++++17.715.511.095.8916.986.04
7668+++tox+++++++17.224.87.556.1213.426.17
7700+++++++++++18.113.915.816.0117.327.96
7747+++++++62.015.015.194.8218.296.26
7766++++++++33.118.06.725.1817.884.14
7860+++++++++20.622.411.164.9616.415.47
7913+(+)++++++14.0n.t.13.505.6418.476.17
7915n.tn.tn.tn.t+++16.013.814.278.4916.216.87

MDA-MB-231/BCRP2.51
A5499.975.54
MT3/ADR3.49

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