Clinical Significance of Skin Toxicity due to EGFR-Targeted Therapies

Table 2

Most common skin toxicities.

Adverse event	Frequency	Description
Rash	60–80%	Monomorphous erythematous maculopapular, follicular, or pustolar lesions which may be associated with pruritus/tenderness
Paronychia and fissuring	6–12%	Painful periungual granulation-type or friable pyogenic granuloma-like changes, associated with erythema, swelling, and fissuring of lateral nailfolds and/or distal finger tufts
Hair changes	5–6%	Alopecia and curlier, finer and more brittle hair on scalp and extremities; trychomegalia and curling of eyebrows and hypertrichosis of the face
Dry skin	4–35%	Diffuse fine scaling
Mucositis	2–36%	Mild to moderate mucositis, stomatitis, and aphthous ulcers
Hypersensitivity reactions	2–3%	Flushicg, urticaria, and anaphylaxis