Journal of Oncology / 2009 / Article / Tab 2 / Research Article
Transcriptional Activity of Human Epidermal Growth Factor Receptor Family and Angiogenesis Effectors in Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma and Correlation with Patient Outcome Table 2 Association of VEGF-C, VEGFR1 (FLT1), and VEGFR3 (FLT4) mRNA expression with clinicopathological parameters.
VEGF-C VEGFR1 (FLT1) VEGFR3 (FLT4) Low High
Low High
Low High
Alcohol consumption .168 .324 .999 Low 4 (20) 9 (45) 8 (40) 5 (25) 7 (35) 6 (32) Moderate 10 (50) 5 (25) 5 (25) 10 (50) 8 (40) 7 (37) High 6 (30) 6 (30) 7 (35) 5 (25) 5 (25) 6 (32) Site of relapse .009 .056 .017 Local only 17 (85) 10 (50) 17 (85) 10 (50) 18 (90) 9 (47) Lymph nodes ± Local 3 (19) 3 (15) 2 (10) 4 (20) 1 (5) 5 (26) Other 0 (0) 7 (35) 1 (5) 6 (30) 1 (5) 5 (26) Size at 1st relapse .712 .110 .999 <2 cm 3 (15) 4 (20) 6 (30) 1 (5) 4 (20) 3 (16) 2–4 cm 10 (50) 9 (45) 11 (55) 10 (50) 11 (55) 9 (47) >4 cm 5 (25) 2 (10) 2 (10) 5 (25) 4 (20) 3 (16) Unknown 2(10) 5 (25) 1 (5) 4 (20) 1 (5) 4 (21) Lymph nodes at diagnosis .342 .047 .041 N0 19 (95) 16 (80) 20 (100) 15 (75) 20 (100) 14 (74) N1-N2 1 (5) 3 (15) 0 (0) 4 (20) 0 (0) 4 (21) Unknown 0 (0) 1 (5) 0 (0) 1 (5) 0 (0) 1 (5) Differentiation grade at relapse .697 .697 .697 Well or moderate 14 (70) 10 (50) 14 (70) 10 (50) 14 (70) 10 (53) Poor or undifferentiated 4 (20 5 (25) 4 (20) 5 (25) 4 (20) 5 (26) Unknown 2 (10) 5 (25) 2 (10) 5 (25) 2 (10) 4 (21) Pack years exposure .341 .341 .751 <52.5 9 (45) 13 (65) 9 (45) 13 (65) 10 (50) 11 (58) >52.5 11 (55) 7 (35) 11 (55) 7 (35) 10 (50) 8 (42) Age .527 .999 .999 <65 9 (45) 12 (60) 11 (55) 10 (50) 10 (50) 10 (53) >65 11 (55) 8 (40) 9 (45) 10 (50) 10 (50) 9 (47) Diagnosis to recurrence interval .333 .748 .748 <12 months 6 (30) 10 (50) 7 (35) 9 (45) 9 (45) 7 (37) >12 months 14 (70) 10 (50) 13 (65) 11 (55) 11 (55) 12 (63)
