TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines
Figure 1
Effect of TJ-41 on the growth of human BrCa cell lines. (a) Two BrCa cell lines (differing in the estrogen receptor status) were cultured in the presence of various concentrations (7.5–750 g/mL) of TJ-41 for 48 hours. Cell proliferation was measured by 3H-Thymidine incorporation in triplicate wells. Results of data derived from three different experiments are expressed as mean percentage of 3H-Thymidine incorporation from triplicate wells as compared to that of control (untreated) cells. All data shown are the of three separate experiments. (b) Depicts the reversible effects of TJ-41 on BrCa Cell lines. MCF-7 and MDA-MB-231 cell were cultured in the presence of 375 g/mL TJ-41 for 2 days. After 2 days, the growth medium was substituted with fresh medium for another 2 days. Cell proliferation was measured by 3H-Thymidine incorporation in triplicate wells. Results of data derived from three different experiments are expressed as mean percentage of 3H-Thymidine incorporation from triplicate wells as compared to that of control (untreated) cells. All data shown are the of three separate experiments.
