A Combination of Systemic and Intracranial Anti-CD25 Immunotherapy Elicits a Long-Time Survival in Murine Model of Glioma

Figure 1

FACS analysis of CD4⁺, CD8⁺, and CD4⁺Foxp3⁺ T cells subsets in the bone marrow of glioma-bearing mice. (a), (b) The frequency of CD4⁺ and CD8⁺ T cells was significantly increased (𝑃<.002) in the bone marrow of glioma-bearing mice as compared to control (glioma-free) mice. (c) Intracellular staining of Foxp3 in gated CD4⁺ T cells from the bone marrow of glioma-bearing and glioma-free mice. Data are shown as the percentage average of positive cells and represent the mean of three independent experiments with three mice per group (𝑃<.002).

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