PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma
Figure 4
In situ distribution of PAI-1 in an early invasive human cutaneous squamous cell carcinoma. Sections were dually stained for PAI-1 (red; (a)) and α-smooth muscle actin (α-SMA, green; (b)). PAI-1 was evident in the SCC epithelium at the invasive front (arrows). Prominent PAI-1-expression also colocalized to α-SMA-positive cells, a marker for myofibroblasts, at the carcinoma periphery. Barbed arrowheads indicate PAI-1/α-SMA at the tumor perimeter while arrowheads depict PAI-1/α-SMA in stromal cells.
