Update in Antiepidermal Growth Factor Receptor Therapy in the Management of Metastatic Colorectal Cancer

Table 1

Comparison between cetuximab and panitumumab.

	Cetuximab	Panitumumab
Structure	Chimeric IgG-1,	Fully humanized: IgG-2
	30% murine
Hypersensitivity reaction	3%	1%
Half life	5 days	7.5 days
Treatment schedule	1-2 weekly	2-weekly
Antibody-dependent cell	Yes	No ADCC reported
mediated cytotoxicity	Fc Domain
(ADCC)	of IgG-1