Review Article

Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer

Figure 2

A diagram summarizing the nuclear and cytoplasmic functions of eIF4E. Some factors that directly regulate eIF4E functions and proteins involved in regulation of eIF4E subcellular distribution are shown. Not all regulators are shown for the sake of clarity. mRNAs are depicted as black lines with black balls denoting the cap and with/without complex UTRs shown in red and 4ESE element shown in green.
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