16 cases of epithelial ovarian malignancy with tubes submitted in toto
fallopian tubes submitted in toto and serially sectioned every 3-4 mm
10 of the 12 cases of high-grade serous carcinoma showed either unilateral tubal mucosal involvement by TIC () or tubal obliteration ipsilateral to the dominant ovarian mass (). In 3 of 5 selected high grade serous carcinoma cases with TICs, FISH analysis showed similar copy number changes in foci of the ovarian and fallopian tube mucosal carcinoma; one case was not synchronous and the 5th was indeterminate
55 cases containing pelvic serous carcinoma (mean age 61.5, range 43–82)
SEE-FIM for all cases
41(75%) showed involvement of endosalpinx; 11 were classified as tubal or peritoneal primary; (9 of these had TICs); 20/30 cases classified as ovarian had TICs; 93% of TICs involved the fimbria. Of 5 ovarian cases with TICs, p53 DNA analysis showed identical mutations in at least one focus of TIC and ovarian cancer
45 cases of primary peritoneal serous carcinoma in which there was either nonuniform sampling of the fallopian tube () or SEE-FIM protocol ()
nonuniform sampling (portion of tube submitted), or SEE-FIM protocol
9 (35%) of first sampling group and 9 (47%) of second samping group showed STICs. 5/5 cases tested showed identical p53 mutations in the peritoneal and tubal lesions
FISH: fluorescence in situ hybridization; SEE-FIM: sectioning and extensively examining the fimbriae; STIC: serous tubal intraepithelial carcinoma; TIC: tubal intraepithelial carcinoma.
