he effect considered has to be at least partial in the processing of an epitope in live cells. n vivo dependence on TPPII for generation of a CTL response against epitope, the column contains the animal used. he requirement for TPPII in the processing of this epitope is debated. vidence in some reports is based only on AAF-CMK, an inhibitor that is however not TPPII-specific. Evidence base: catalytic inhibitor—&; siRNA—@; gene-deficient cells—. T: Gene-trapped TPPII-deficient mouse. nly in the presence of proteasomal inhibitor. Cells: Dendritic cells, COS: Chinese Hamster Ovary cells, LCL: Lymphoblastoid cells, HEK293: Human embryonic kidney cells, BMC-2 and J-774 - macrophage cell lines, BMM: Bone-marrow macrophages.