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Journal of Oncology
Volume 2010, Article ID 135285, 12 pages
http://dx.doi.org/10.1155/2010/135285
Review Article

Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis

Department of Radiopharmaceutical Biology, Institute of Radiopharmacy, Research Center Dresden-Rossendorf, 01328 Dresden, Germany

Received 2 December 2009; Accepted 5 January 2010

Academic Editor: Arkadiusz Dudek

Copyright © 2010 Birgit Mosch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Eph receptors and their ephrin ligands were identified in the late 1980's. Subsequently, they were linked to different physiological and pathophysiological processes like embryonic development, angiogenesis, and tumorigenesis. In this regard, recent work focused on the distribution and effects of Eph receptors and ephrins on tumor cells and tumor microenvironment. The purpose of this review is to outline the role of these molecules in physiological angiogenesis and pathophysiological tumor angiogenesis. Furthermore, novel therapeutical approaches are discussed as Eph receptors and ephrins represent attractive targets for antiangiogenic therapy.