The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

Figure 2

Development of vaginal papiloma and increased apoptosis in K-ras^G12D mice. (a) The development of vaginal papiloma. Control and K-ras^G12D mice at 2 months of age. (b) H&E staining of vagina of control and K-ras^G12D mice. The histology of these lesions revealed an abnormal vaginal architecture in the K-ras^G12D mice compared to controls. (c) TUNEL assay in the uterus of control and K-ras^G12D mice at 2 months of age. The number of apoptotic cells was significantly increased in epithelial cells of K-ras^G12D uteri compared to controls. Scale bar: 100 𝜇m.

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