The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

Figure 3

Development of endometrial cancer in mice with Pten ablation and oncogenic K-ras mutation. (a) Gross anatomy of control, K-ras^G12D, Pten^d/d, and Pten^d/dK-ras^G12D uteri at 2 and 4 weeks of age. Scale bar: 1 cm (b) The ratio of uterine weight to body weight in control, K-ras^G12D, Pten^d/d, and Pten^d/dK-ras^G12D mice at 2 and 4 weeks of age. Uterine weight was determined for females 2 and 4 weeks old. Increased uterine weight was observed for Pten^d/dK-ras^G12D mice after 2 weeks of age. *, 𝑃<.05; ^***, 𝑃<.001, one-way ANOVA followed by Tukey’s post hoc multiple range test.

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